苯那普利对糖尿病大鼠肾脏细胞凋亡及Fas和Fas-L表达的影响

被引：8

作者：

张新爽

刘亚玲

张艳玲

机构：

[1] 河北省衡水市中医院

[2] 邯郸钢铁公司职工医院

[3] 河北医科大学第三医院

来源：

河北医药 | 2003年 / 04期

关键词：

血管紧张素转换酶抑制剂; 糖尿病肾病; 细胞凋亡; Fas; Fas-L;

D O I：

暂无

中图分类号：

R587.1 [糖尿病];

学科分类号：

1002 ; 100201 ;

摘要：

目的　探讨血管紧张素转换酶抑制剂 (ACEI)对糖尿病肾脏细胞凋亡及凋亡相关蛋白的影响。方法　单侧肾切除大鼠腹腔注射STZ(65mg kg)诱发糖尿病模型 ,每日灌胃给予ACEI苯那普利(10mg kg) ,共 12周。采用原位末端标记法检测肾脏细胞凋亡情况 ,流式细胞术和免疫组化检测肾皮质Fas和Fas L表达。结果　糖尿病组较对照组肾小球、肾小管凋亡细胞数明显增多 ,Fas和Fas L的表达亦显著增强 ,苯那普利治疗组较糖尿病组凋亡细胞数减少 ,Fas和Fas L的表达减弱。结论　苯那普利可能通过影响凋亡相关蛋白Fas和Fas L的表达而抑制肾脏细胞凋亡 ,从而发挥肾脏保护作用。

引用

页码：243 / 245

页数：3

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