Lgr5-Wnt/β-catenin信号通路与胃癌干细胞的研究进展

被引：12

作者：

牛磊

郗洪庆

陈凛

机构：

[1] 解放军总医院普通外科

来源：

解放军医学院学报 | 2014年 / 35卷 / 12期

关键词：

胃癌干细胞; Wnt基因; β-连环蛋白; 富含亮氨酸G蛋白偶联受体5;

D O I：

暂无

中图分类号：

R735.2 [胃肿瘤];

学科分类号：

100112 [医学生物化学与分子生物学];

摘要：

随着基础研究领域的不断拓展和深入,胃癌的难治性逐渐被归因于胃癌干细胞的存在和信号通路的异常表达,其中最具代表性的当属Wnt/β-catenin信号通路。Lgr5作为Wnt/β-catenin通路的受体蛋白亦被认为是众多恶性肿瘤干细胞潜在的分子标记物。我们将就Lgr5-Wnt/β-catenin信号通路与胃癌干细胞之间的相互关系,结合目前研究进展进行综述。

引用

页码：1268 / 1272

页数：5

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