枸杞提取液对实验性肾动脉狭窄性高血压损伤鼠的治疗

被引：5

作者：

祝捷 ^{[1
]}

迟焕芳 ^{[1
]}

王守彪 ^{[1
]}

陶涛 ^{[2
]}

机构：

[1] 青岛大学医学院解剖学教研室

[2] 淄博市中心医院

来源：

现代生物医学进展 | 2008年 / 01期

关键词：

枸杞提取液; 氧自由基; 肾源性高血压; bcl-2;

D O I：

10.13241/j.cnki.pmb.2008.01.018

中图分类号：

R285.5 [中药实验药理];

学科分类号：

摘要：

目的:探讨枸杞提取液对高血压疾病的治疗作用和可能的机制。方法:将30只健康SD大鼠随机分为正常组,对照组和治疗组,每组10只。对照组和治疗组建立肾动脉狭窄性高血压模型,治疗组每日给予枸杞提取液灌胃处理,对照组给予生理盐水灌胃处理。饲养一个月后,取SD大鼠心脏、肾脏、大脑做组织病理学方面的检测。结果:与对照组相比较,治疗组血压明显下降(P<0.05),血浆NO合酶cGMP含量明显上升(P<0.05),心肌细胞横截面积有统计性差异(P<0.05);心肌组织结构接近正常,且脑血管病理改变轻。对照组的肾、心、脑组织内cGMP水平与正常组相比显著升高,治疗组cGMP水平较对照组降低,且差别有统计学意义。与对照组和正常组相比,治疗组大鼠心、肾凋亡阳性细胞计数差异均有统计学意义(P<0.05)。凋亡因子Bcl-2水平在脑组织内表达显示了组间的差异显著。结论:枸杞提取液对肾源性高血压造成的脏器损害具有保护作用,能够预防由于氧自由基造成的损伤,其作用机制与调节血管活性物质水平和抗氧自由基损伤有关。

引用

页码：16 / 18

页数：3

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