可溶性CD40配体与冠脉病变的相关性研究

被引：2

作者：

杨兆宇

机构：

[1] 昆明市西山区人民医院

来源：

大理学院学报(自然科学) | 2006年 / 10期

关键词：

可溶性CD40配体; 不稳定斑块; 冠脉病变;

D O I：

暂无

中图分类号：

R541.4 [冠状动脉（粥样）硬化性心脏病（冠心病）];

学科分类号：

摘要：

目的:通过分析可溶性细胞表面分化抗原40配体(sCD40L)水平与冠脉病变的关系,探讨其在冠心病发病中的意义。方法:经冠脉造影确诊的冠心病患者,对冠脉病变程度进行分型,ELISA法检测血浆中sCD40L含量,分析sCD40L水平与冠脉病变程度的相关性。结果:CHD组与对照组相比,sCD40L明显增加,且随冠脉病变累计支数越多、病变越严重,sCD40L水平增高越明显。单因素相关分析显示sCD40L水平与病变支数、病变类型呈正相关关系。结论:sCD40L对ACS不稳定斑块有促进作用,通过检测其表达水平,可能对预测动脉粥样硬化的启动和进展、斑块的易损性等提供新的资料,最终可能指导治疗。

引用

页码：44 / 46

页数：3

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