脊髓损伤后中枢性疼痛的实验模型和机制研究进展

被引：6

作者：

谢永刚

张小洺

姚尚龙

机构：

[1] 华中科技大学同济医学院附属协和医院麻醉科

来源：

国际麻醉学与复苏杂志 | 2006年 / 06期

关键词：

spinal cord injury; central pain; experimental models; mechanisms;

D O I：

暂无

中图分类号：

R651.2 [脊髓];

学科分类号：

1002 ; 100210 ;

摘要：

Central pain(CP) following spinal cord injury challenges the health care community.A number of pain syndromes associated with spinal cord injury are based on the nature of the lesion,neurological structure damage and secondary pathophysiological changes.The treatment of these patients will remain the same as for any other type of pain if one does not understand the different mechanisms.So it is very important to study the mechanisms according to appropriate animal models.

引用

页码：357 / 360

页数：4

共 19 条

[1]

Spared nerve in jury:an an imal model ofpersistent peripheral neuropath ic pain. D ecosterd CJ,W oolf CJ. Pain . 2000

[2]

P lasticity of sp inal n icotin ic acetylcholine re-ceptors follow ing sp inal nerve ligation. V inclerM,E isenach JC. Neurosciences Research . 2004

[3]

E lectrophysiologicalcharacterisations of rat lam ina I dorsal horn neurones and the involve-m ent of excitatory am ino acid receptors. Seagrove L,Suzuk i R,D ickenson AH,et al. Pain . 2004

[4]

Transplants of adrenalm edu llary chromaffincells reduce forelimb and h ind limb allodyn ia in a rodent model ofchron ic central pain after sp inal cord hem isection in jury. Hains BC,EverhartAW. Exp neuron . 2000

[5]

A ltered patterns of reflex ex-citab ility subsequent to contusion in jury of the rat sp inal cord. Thompson FJ,Reier PJ,Lucas CC,et al. Journal of Neurophysiology . 1992

[6]

Phantom body pain in paraplegies:evidencefor a central pattern generating m echan ism for pain. M elzack R,Loeser JD. Pain . 1978

[7]

Photochem ically induced transientsp inal is chem ia induces behavioral hypersensitivity to m echan ical andcold stimu li,but not to noxious heat stimu li in the rat. Hao JX,Xu X J,A ldskogius,et al. Experimental Neurology . 1992

[8]

Transient sp inal ischem ia in rat:characterization of sp inal cord b lood flow,extracellu lar am inoacid re-lease,and concurrent h istopathological damage. Marsala M,Sork in LS,Yaksh TL. J Cereb B lood FlowM etab . 1994

[9]

Contribution of degeneration ofmotor and sensory fibers to pain behavior and the changes in neurotro-ph ic factors inrat dorsal root ganglion. Obata K,Yamanaka H,Dai Y,et al. Experim entalNeurology . 2004

[10]

Contribution of degeneration ofmotor and sensory fi-bers to pain behavior and the charges in neurotroph ic factors in rat dor-sal root ganglion. Obata K,Dai Y. Experim ental neurology . 2004

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