影响心肌粘弹性的细胞分子机制

被引:1
作者
李进嵩
黄晶
机构
[1] 重庆医科大学附属第二医院心血管科
关键词
心肌粘弹性; 肌联蛋白; 微管; 胶原纤维; 舒张性心力衰竭;
D O I
暂无
中图分类号
R318.01 [生物力学];
学科分类号
0831 ;
摘要
松弛状态心肌是一种粘弹性材料。心肌粘弹性是决定心脏舒张功能的主要因素。为加深对舒张性心力衰竭病理生理机制的认识,笔者查阅了近年来国内外有关研究心肌粘弹性影响因素的文献,表明心肌细胞内的肌联蛋白、微管和细胞外胶原纤维是影响心肌粘弹性的重要因素,笔者就上述心肌粘弹性影响因素作一综述。
引用
收藏
页码:261 / 263
页数:3
相关论文
共 12 条
[1]  
The Giant Protein Titin: A Major Player in Myocardial Mechanics, Signaling, and Disease[J] . Henk L. Granzier,Siegfried Labeit.Circulation Research: Journal of the American Heart Association . 2004 (3)
[2]   Cycling cross-bridges increase myocardial stiffness at submaximal levels of Ca2+ activation [J].
Campbell, KS ;
Patel, JR ;
Moss, RL .
BIOPHYSICAL JOURNAL, 2003, 84 (06) :3807-3815
[3]  
Molecular Basis of Passive Stress Relaxation in Human Soleus Fibers: Assessment of the Role of Immunoglobulin-Like Domain Unfolding[J] . K. Trombitás,Y. Wu,M. McNabb,M. Greaser,M.S.Z. Kellermayer,S. Labeit,H. Granzier.Biophysical Journal . 2003 (5)
[4]   Titin isoform switch in ischemic human heart disease [J].
Neagoe, C ;
Kulke, M ;
del Monte, F ;
Gwathmey, JK ;
de Tombe, PP ;
Hajjar, RJ ;
Linke, WA .
CIRCULATION, 2002, 106 (11) :1333-1341
[5]  
Cardiac titin: molecular basis of elasticity and cellular contribution to elastic and viscous stiffness components in myocardium[J] . Wolfgang A. Linke,Julio M. Fernandez.Journal of Muscle Research and Cell Motility . 2002 (5)
[6]  
Interaction Between PEVK-Titin and Actin Filaments: Origin of a Viscous Force Component in Cardiac Myofibrils[J] . M. Kulke,S. Fujita-Becker,E. Rostkova,C. Neagoe,D. Labeit,D. J. Manstein,M. Gautel,W. A. Linke.Circulation Research: Journal of the American Heart Association . 2001 (10)
[7]  
Titin–Actin Interaction in Mouse Myocardium: Passive Tension Modulation and Its Regulation by Calcium/S100A1[J] . R. Yamasaki,M. Berri,Y. Wu,K. Trombitás,M. McNabb,M.S.Z. Kellermayer,C. Witt,D. Labeit,S. Labeit,M. Greaser,H. Granzier.Biophysical Journal . 2001 (4)
[8]   Role of microtubules in the viscoelastic properties of isolated cardiac muscle [J].
Yamamoto, S ;
Tsutsui, H ;
Takahashi, M ;
Ishibashi, Y ;
Tagawa, H ;
Imanaka-Yoshida, K ;
Saeki, Y ;
Takeshita, A .
JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY, 1998, 30 (09) :1841-1853
[9]  
The Giant Protein Titin: Emerging Roles in Physiology and Pathophysiology[J] . Siegfried Labeit,Bernhard Kolmerer,Wolfgang A. Linke.Circulation Research . 1997 (2)
[10]   Cytoskeletal mechanics in pressure-overload cardiac hypertrophy [J].
Tagawa, H ;
Wang, N ;
Narishige, T ;
Ingber, DE ;
Zile, MR ;
Cooper, G .
CIRCULATION RESEARCH, 1997, 80 (02) :281-289