呼吸道黏膜防御机制与慢性阻塞性肺部疾病

[1] Reduced epithelial expression ofsecretory component in small airways correlates with airflow obstruction in chronic obstructive pulmonary disease. Pilette C,Godding V,Kiss R,Delos M,Verbeken E,Decaestecker C,De Paepe K,Vaerman JP,Decramer M,Sibille Y. American Journal of Respiratory and Critical Care Medicine . 2001

[2] O-ral Purified Bacterial Extracts in Chronic Bron-chitis and COPD. Claudia Steurer-Stey,MD,Lucas M,Bach-mann,MD,PhD,Johann Steurer MD,et al. Chest . 2004

[3] Secretory component is cleaved by neutrophil serine proteinases but its epithelial production is increased by neutrophils through NF-kappa B- and p38 mitogen-activated protein kinase-dependent mechanisms. Pilette C,,Ouadrhiri Y,Dimanche F, et al. Am J Respir Cell Mol Biol . 2003

[4] Intranasal i mmuniza-tion with a colloid-formulated bacterial extract induces an acute inflammatory response in the lungs and elicits spe-cific i mmune responses. Rial A,Lens D,Betancor L et al. Infection and Immunity . 2004

[5] Inhaled corticosteroids in chronic ob-structive pul monary disease:is there a clinical benefit?. Man SF,Sin DD. Drugs . 2005

[6] Short-term and long-termoutcomes of moxifloxacin compared to standard antibiotic treat ment in acute exacerbations of chronicbronchitis. Wilson R,Allegra L,Huchon G et al. Chest . 2004

[7] Activation of NF-kappa B by nontypeable Hemophilus influenzae is mediated by toll-like receptor2-TAK1-dependent NIK-IKKalpha/be-ta-I kappa B alpha and MKK3/6-p38MAP kinase signa-ling pathways in epithelial cells. Shuto T,Xu H,Wang Bet al. Proceedings of the National Academy of Sciences of the United States of America . 2001

[8] Haemophilus in-fluenzae frompatients with chronic obstructive pul monary disease exacerbation induce more inflammation than colo-nizers. Chin CL,Manzel LJ,Lehman EEet al. American Journal of Respiratory and Critical Care Medicine . 2005

[9] Innate i mmunity in the lung:how epithelial cells fight against respiratory pathogens. Bals R,Hiemstra PS. European Respiratory Journal . 2004

[10] Mucosal i m-munity in asthma and chronic obstructive pul monary dis-ease:a role for i mmunoglobulin A?. Pilette C,Durham SR,Vaerman JP et al. Proc Am Thorac Soc . 2004

[1] Reduced epithelial expression ofsecretory component in small airways correlates with airflow obstruction in chronic obstructive pulmonary disease. Pilette C,Godding V,Kiss R,Delos M,Verbeken E,Decaestecker C,De Paepe K,Vaerman JP,Decramer M,Sibille Y. American Journal of Respiratory and Critical Care Medicine . 2001

[2] O-ral Purified Bacterial Extracts in Chronic Bron-chitis and COPD. Claudia Steurer-Stey,MD,Lucas M,Bach-mann,MD,PhD,Johann Steurer MD,et al. Chest . 2004

[3] Secretory component is cleaved by neutrophil serine proteinases but its epithelial production is increased by neutrophils through NF-kappa B- and p38 mitogen-activated protein kinase-dependent mechanisms. Pilette C,,Ouadrhiri Y,Dimanche F, et al. Am J Respir Cell Mol Biol . 2003

[4] Intranasal i mmuniza-tion with a colloid-formulated bacterial extract induces an acute inflammatory response in the lungs and elicits spe-cific i mmune responses. Rial A,Lens D,Betancor L et al. Infection and Immunity . 2004

[5] Inhaled corticosteroids in chronic ob-structive pul monary disease:is there a clinical benefit?. Man SF,Sin DD. Drugs . 2005

[6] Short-term and long-termoutcomes of moxifloxacin compared to standard antibiotic treat ment in acute exacerbations of chronicbronchitis. Wilson R,Allegra L,Huchon G et al. Chest . 2004

[7] Activation of NF-kappa B by nontypeable Hemophilus influenzae is mediated by toll-like receptor2-TAK1-dependent NIK-IKKalpha/be-ta-I kappa B alpha and MKK3/6-p38MAP kinase signa-ling pathways in epithelial cells. Shuto T,Xu H,Wang Bet al. Proceedings of the National Academy of Sciences of the United States of America . 2001

[8] Haemophilus in-fluenzae frompatients with chronic obstructive pul monary disease exacerbation induce more inflammation than colo-nizers. Chin CL,Manzel LJ,Lehman EEet al. American Journal of Respiratory and Critical Care Medicine . 2005

[9] Innate i mmunity in the lung:how epithelial cells fight against respiratory pathogens. Bals R,Hiemstra PS. European Respiratory Journal . 2004

[10] Mucosal i m-munity in asthma and chronic obstructive pul monary dis-ease:a role for i mmunoglobulin A?. Pilette C,Durham SR,Vaerman JP et al. Proc Am Thorac Soc . 2004