人参皂苷Rg1对大鼠海马c-fos基因表达和cAMP含量的影响(英文)

被引:23
作者
刘忞
张均田
机构
[1] 中国医学科学院药物研究所
[2] 中国医学科学院药物研究所 北京 中国
[3] 北京 中国
关键词
人参; 皂苷类; fos基因; 原癌基因蛋白c-fos; 腺苷环一磷酸; RNA印迹; 蛋白质印迹; 海马;
D O I
暂无
中图分类号
R285 [中药药理学];
学科分类号
1008 ;
摘要
目的:探讨Rg1对神经系统作用的机制。方法:采用Northern和Western印迹分析法,检测了Rg1处理前后大鼠海马组织的c-fos基因和蛋白的表达。结果:老年鼠c-fos基因和蛋白的表达明显低于青年鼠,但给Rg1后老年鼠和青年鼠均呈现显著性增强效应。此外,Rg1还明显增加青年鼠和老年鼠海马组织的cAMP含量。结论:Rg1升高cAMP水平及促进c-fos基因和蛋白的表达有助于阐明其促智和抗衰老作用的机制。
引用
收藏
页码:77 / 80
页数:4
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