慢加急性肝衰竭患者血清二胺氧化酶水平及其临床意义探讨

被引：2

作者：

朱玉成 ^{[1
]}

闫家微 ^{[2
]}

孙景坤 ^{[1
]}

张秋月 ^{[3
]}

机构：

[1] 江苏省徐州市传染病医院重症医学科

[2] 江苏省徐州市传染病医院检验科

[3] 徐州医科大学附属医院消化科

来源：

实用肝脏病杂志 | 2019年 / 22卷 / 05期

关键词：

慢加急性肝衰竭; 乙型肝炎; 二胺氧化酶; 预后;

D O I：

暂无

中图分类号：

R575.3 [肝功能衰竭];

学科分类号：

100201 [内科学];

摘要：

目的探讨乙型肝炎相关的慢加急性肝衰竭(ACLF)患者血清二胺氧化酶(DAO)水平及其评估患者预后的价值。方法 2014年8月～2017年4月我院收治的104例ACLF患者,在治疗60 d内,生存64例,死亡40例。采用酶联免疫吸附法检测血清DAO水平,采用二元Logistic回归分析影响患者预后的因素。结果生存患者血清DAO水平为(15.1±4.8) ng/mL,显著低于死亡患者[(68.4±25.4) ng/mL,P<0.05];单因素分析显示年龄、TBIL、AST、ALT、INR、ALB、Cr、MEID评分、WBC、自发性细菌腹膜炎、肝性脑病、腹水和肝硬化与患者预后结局相关,多因素回归分析显示,MELD评分、年龄和血清DAO水平为影响患者预后的独立危险因素;DAO≥48.7 ng/mL与DAO<48.7 ng/mL患者生存率分别为50.0%和77.3%,差异有统计学意义(P<0.05),MELD≥26.1分与MELD<26.1分患者生存率分别为45.5%和79.6%,差异有统计学意义(P<0.05),年龄≥40岁与年龄<40岁的患者生存率分别为50.8%和79.5%,差异有统计学意义(P<0.05)。结论血清DAO水平也可以判断ACLF患者预后,为判断肝衰竭患者预后增加了一个可应用的指标,其作用还有待于进一步研究。

引用

页码：672 / 675

页数：4

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