洛索洛芬治疗膝骨关节炎的临床评价

被引：14

作者：

李胜光

崔鸿雁

郭军华

杨春花

黄烽

机构：

[1] 解放军总医院风湿科!北京

来源：

中国新药杂志 | 2000年 / 12期

关键词：

乐松; 骨关节炎; 疗效;

D O I：

暂无

中图分类号：

R684 [关节疾病及损伤];

学科分类号：

摘要：

目的 :观察洛索洛芬 (乐松 )治疗膝骨关节炎 (OA)的疗效和安全性。方法 :选择 114例膝OA患者 ,口服乐松 ,6 0mg ,tid。分别在 0周和第 3周末进行疗效和安全性评估 ,疗效指标包括休息时痛、活动痛指数、关节压痛、关节肿胀和关节活动度等 5项指标。结果 :完成疗程、资料齐全的患者共 10 6例。经过 3周的治疗 ,乐松对患者5项疗效指标均有明显改善 (P <0 .0 1) ,各项指标的有效率均超过 80 .0 % ;医师和患者对疗效评定的总有效率分别为 89.6 2 %和 91.5 1%。 13例 (12 .2 6 % )患者出现了与药物相关的不良反应 ,全部为胃肠道症状 ,勿需减量或停药 1周内症状消失。无严重的或危及生命的不良反应发生。结论 :乐松具有强大的消炎镇痛作用 ,不良反应轻 ,依从性较好

引用

页码：856 / 859

页数：4

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