脂蛋白脂酶与动脉粥样硬化

被引:13
作者
张晓刚
陈运贞
机构
[1] 重庆医科大学附属第一医院心内科!重庆
关键词
脂蛋白脂酶; 动脉粥样硬化; 冠心病;
D O I
暂无
中图分类号
R363 [病理生理学];
学科分类号
摘要
脂蛋白脂酶为脂质代谢的重要酶 ,在体内分布脏器不同 ,表现出不同的作用特点。脂蛋白脂酶在血浆中具有水解甘油三酯作用 ,对防治动脉粥样硬化病变有利。在动脉壁内 ,细胞基质中的脂蛋白脂酶有滞留蛋白作用 ;巨噬细胞膜上的脂蛋白脂酶能促进低密度脂蛋白和极低密度脂蛋白进入该细胞内 ,使巨噬细胞转变为泡沫细胞 ;脂蛋白脂酶还能刺激血管壁平滑肌细胞增生等 ,脂蛋白脂酶表现出致动脉粥样硬化作用。本文还综述了多种体内外因素对脂蛋白脂酶代谢与活性的影响。
引用
收藏
页码:128 / 129
页数:2
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