共 1 条
[1]
Center for drug evaluation and resarch. FDA. Application Number 020895 . 1998
光度法测定枸橼酸西地那非及尿中西地那非的含量
被引：2
作者：
江虹
湛海粼
吴兴发
机构：
[1] 涪陵师范学院化学系
[2] 涪陵广播电视大学
[3] 涪陵师范学院化学系 重庆
[4] 重庆
来源：
关键词：
光度法;
枸橼酸西地那非;
尿样;
乙基曙红;
D O I：
暂无
中图分类号：
TQ463 [有机化合物药物的生产];
O657.3 [光化学分析法（光谱分析法）];
学科分类号：
1007 ;
070302 ;
081704 ;
摘要：
In the condition of pH 2.5～4.7,ethyl eosin reacts with sildenafil to form red ion association complexes.The maximum absorption wavelengths and the maximum fading wavelengths were 550 nm and 520 nm,respectively.The apparent molar absorptivities（ε）were 2.09×10～4 and 2.44×10～4L·mol-1·cm-1,respectively.When the dual-wavelength overlapping absorption spectrometry was used to determine the sidenafi,their apparent molar absorptivity ε was increased to 4.57×10～4 L·mol-1·cm-1.The method was applied to the determination of the content of the agora sell and in human urine sildenafils with satisfactory results.
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页码：573 / 574
页数：2
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