远志寡糖酯类化合物药理活性研究进展

被引:50
作者
桑旭星
杨依
方芳
机构
[1] 北京中医药大学中药学院
关键词
远志; 寡糖酯; 药理活性;
D O I
暂无
中图分类号
R285.5 [中药实验药理];
学科分类号
100806 [中药药理学];
摘要
随着对远志(Polygala tenuifolia Willd.)化学成分的研究,远志寡糖酯类成分越来越受到关注,现代药理研究发现,该类成分具有脑保护、抗抑郁等多种药理活性。笔者对其药理作用及作用机制研究进行综述,为进一步研究远志抗痴呆等神经保护作用提供线索和思路。
引用
收藏
页码:1576 / 1579
页数:4
相关论文
共 10 条
[1]
Tenuifoliside A promotes neurite outgrowth in PC12 cells via the PI3K/AKT and MEK/ERK/CREB signaling pathways [J].
Liu, Xiaoxing ;
Wang, Xiaolin ;
Lu, Jun .
MOLECULAR MEDICINE REPORTS, 2015, 12 (05) :7637-7642
[2]
Neuroprotective Effects of 3,6′-Disinapoyl Sucrose Through Increased BDNF Levels and CREB Phosphorylation via the CaMKII and ERK1/2 Pathway [J].
Hu, Yuan ;
Liu, Ming-Yue ;
Liu, Ping ;
Dong, XianZhe ;
Boran, Aislyn D. W. .
JOURNAL OF MOLECULAR NEUROSCIENCE, 2014, 53 (04) :600-607
[3]
The inhibition of JNK MAPK and NF-κB signaling by tenuifoliside A isolated from Polygala tenuifolia in lipopolysaccharide-induced macrophages is associated with its anti-inflammatory effect [J].
Kim, Kyoung-Su ;
Lee, Dong-Sung ;
Bae, Gi-Sang ;
Park, Sung-Joo ;
Kang, Dae-Gil ;
Lee, Ho-Sub ;
Oh, Hyuncheol ;
Kim, Youn-Chul .
EUROPEAN JOURNAL OF PHARMACOLOGY, 2013, 721 (1-3) :267-276
[4]
Protection of SH-SY5Y Neuronal Cells from Glutamate-Induced Apoptosis by 3; 6 ′ -Disinapoyl Sucrose; a Bioactive Compound Isolated from Radix Polygala.[J].Yuan Hu;Jie Li;Ping Liu;Xu Chen;Dai-Hong Guo;Qing-Shan Li;Khalid Rahman;Masa-Aki Shibata.Journal of Biomedicine and Biotechnology.2011,
[5]
Potential antidepressant properties of Radix Polygalae (Yuan Zhi) [J].
Liu, P. ;
Hu, Y. ;
Guo, D. -H. ;
Wang, D. -X. ;
Tu, H. -H. ;
Ma, L. ;
Xie, T. -T. ;
Kong, L. -Y. .
PHYTOMEDICINE, 2010, 17 (10) :794-799
[6]
Antioxidant activity of oligosaccharide ester extracted from Polygala tenuifolia roots in senescence-accelerated mice [J].
Liu, Ping ;
Hu, Yuan ;
Guo, Dai-Hong ;
Lu, Bao-Rong ;
Rahman, Khalid ;
Mu, Li-Hua ;
Wang, Dong-Xiao .
PHARMACEUTICAL BIOLOGY, 2010, 48 (07) :828-833
[7]
Antidepressant-like effects of 3;6′-disinapoyl sucrose on hippocampal neuronal plasticity and neurotrophic signal pathway in chronically mild stressed rats.[J].Yuan Hu;Hong-Bo Liao;Guo Dai-Hong;Ping Liu;Yu-Yu Wang;Khalid Rahman.Neurochemistry International.2009, 3
[8]
远志寡糖酯类化合物及远志酮Ⅲ对CYP450酶的活性影响研究.[J].李照亮;董宪喆;王东晓;董瑞华;郭婷婷;孙艳;刘屏;.中国中药杂志.2014, 22
[9]
远志中的三萜皂苷和寡糖多酯类成分(英文) [J].
李创军 ;
杨敬芝 ;
庾石山 ;
张东明 ;
薛微 ;
苑玉和 ;
陈乃宏 .
中国天然药物, 2011, 9 (05) :321-328
[10]
远志科植物中的寡糖酯类成分 [J].
杨学东 ;
张丽杰 ;
梁波 ;
徐丽珍 ;
杨世林 .
中草药, 2002, (10)