炎症性肠疾病的微生态调节治疗

被引:2
作者
周密妹
王静
尹丽芳
周园园
机构
[1] 武汉科技大学附属医院临床药学室
关键词
炎性肠疾病; 免疫,天然; 药物疗法; 共生菌; 益生菌;
D O I
暂无
中图分类号
R574 [肠疾病];
学科分类号
100201 [内科学];
摘要
炎症性肠病包括溃疡性结肠炎、克罗恩病等,表现为肠黏膜免疫系统对肠内共生细菌产生异常反应的一类慢性肠道疾病,有明显家族聚集性但病因不明,肠道与其共栖微生物的稳态平衡一旦破坏即可发病。不同遗传个体对有害菌、无害菌或益生菌等肠内共生菌呈现不同的反应性,而肠内共生菌对肠道卫生以及天然免疫和获得免疫间的互动具有重要作用。
引用
收藏
页码:143 / 148
页数:6
相关论文
共 8 条
[1]
Therapeutic approaches targeting intestinal microflora in inflammatory bowel disease [J].
Andoh, Akira ;
Fujiyama, Yoshihide .
WORLD JOURNAL OF GASTROENTEROLOGY, 2006, 12 (28) :4452-4460
[2]
Specificities of the fecal microbiota in inflammatory bowel disease [J].
Sokol, H ;
Seksik, P ;
Rigottier-Gois, L ;
Lay, C ;
Lepage, P ;
Podglajen, I ;
Marteau, P ;
Doré, J .
INFLAMMATORY BOWEL DISEASES, 2006, 12 (02) :106-111
[3]
Mechanism of pathogen-specific TLR4 activation in the mucosa: Fimbriae, recognition receptors and adaptor protein selection [J].
Fischer, H ;
Yamamoto, M ;
Akira, S ;
Beutler, B ;
Svanborg, C .
EUROPEAN JOURNAL OF IMMUNOLOGY, 2006, 36 (02) :267-277
[4]
Microbial colonization induces oligoclonal expansions of intraepithelial CD8 T cells in the gut [J].
Helgeland, L ;
Dissen, E ;
Dai, KZ ;
Midtvedt, T ;
Brandtzaeg, P ;
Vaage, JT .
EUROPEAN JOURNAL OF IMMUNOLOGY, 2004, 34 (12) :3389-3400
[5]
The metabolic activity of fecal microbiota from healthy individuals and patients with inflammatory bowel disease [J].
Van Nuenen, MHMC ;
Venema, K ;
Van der Woude, JCJ ;
Kuipers, EJ .
DIGESTIVE DISEASES AND SCIENCES, 2004, 49 (03) :485-491
[6]
MyD88-deficient mice develop severe intestinal inflammation in dextran sodium sulfate colitis [J].
Araki, A ;
Kanai, T ;
Ishikura, T ;
Makita, S ;
Uraushihara, K ;
Iiyama, R ;
Totsuka, T ;
Takeda, K ;
Akira, S ;
Watanabe, M .
JOURNAL OF GASTROENTEROLOGY, 2005, 40 (01) :16-23
[7]
Germinated barley foodstuff prolongs remission in patients with ulcerative colitis [J].
Hanai, H ;
Kanauchi, O ;
Mitsuyama, K ;
Andoh, A ;
Takeuchi, K ;
Takayuki, I ;
Araki, Y ;
Fujiyama, Y ;
Toyonaga, A ;
Sata, M ;
Kojima, A ;
Fukuda, M ;
Bamba, T .
INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE, 2004, 13 (05) :643-647
[8]
Prebiotic treatment of experimental colitis with germinated barley foodstuff: A comparison with probiotic or antibiotic treatment [J].
Fukuda, M ;
Kanauchi, O ;
Araki, Y ;
Andoh, A ;
Mitsuyama, K ;
Takagi, K ;
Toyonaga, A ;
Sata, M ;
Fujiyama, Y ;
Fukuoka, M ;
Matsumoto, Y ;
Bamba, T .
INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE, 2002, 9 (01) :65-70