Calpains活化与细胞凋亡的相关研究进展

被引：5

作者：

李小平

刘唐威

机构：

[1] 广西医科大学第一附属医院心内科

来源：

医学综述 | 2010年 / 16卷 / 09期

关键词：

钙激活中性蛋白酶; 细胞凋亡; 半胱氨酸蛋白酶家族; 半胱氨酸天冬氨酸蛋白酶;

D O I：

暂无

中图分类号：

R363 [病理生理学];

学科分类号：

100103 [病原生物学];

摘要：

Calpains是一种胞内半胱氨酸蛋白酶,主要由胞内钙离子浓度的升高所激活。近年来的研究发现calpains与细胞凋亡有关。相关试验表明,活化后的calpains可通过剪切有关凋亡分子蛋白如Bcl-2,Bax,Bid和p53等,以及直接剪切并活化caspase-3、caspase-7等方式,从而参与调控细胞凋亡的病理过程。

引用

页码：1291 / 1293

页数：3

共 7 条

[1]

Calpain-1 induces apoptosis in pulmonary microvascular endothelial cells under septic conditions [J].

Hu, Houxiang ;

Li, Xiaoping ;

Li, Ying ;

Wang, Lefeng ;

Mehta, Sanjay ;

Feng, Qingping ;

Chen, Ruizhen ;

Peng, Tianqing .

MICROVASCULAR RESEARCH, 2009, 78 (01) :33-39

[2]

Calpain activation causes a proteasome-dependent increase in protein degradation and inhibits the Akt signalling pathway in rat diaphragm muscle [J].

Smith, Ira J. ;

Dodd, Stephen L. .

EXPERIMENTAL PHYSIOLOGY, 2007, 92 (03) :561-573

[3]

Tumor necrosis factor- $$\alpha$$ induces caspase-independent cell death in human neutrophils via reactive oxidants and associated with calpain activity.[J].Hao-Cheng Chen;Chih-Jan Wang;Chun-Liang Chou;Shu-Min Lin;Chien-Da Huang;Ting-Yu Lin;Chun-Hua Wang;Horng-Chyuan Lin;Chih-Teng Yu;Han-Pin Kuo;Chien-Ying Liu.Journal of Biomedical Science.2006, 2

[4]

Kinetics of Smac/DIABLO release from mitochondria during apoptosis of MCF-7 breast cancer cells [J].

Gorka, M ;

Godlewski, MM ;

Gajkowska, B ;

Wojewodzka, U ;

Motyl, T .

CELL BIOLOGY INTERNATIONAL, 2004, 28 (11) :741-754

[5]

Domain III of calpain is a Ca2+-regulated phospholipid-binding domain [J].

Tompa, P ;

Emori, Y ;

Sorimachi, H ;

Suzuki, K ;

Friedrich, P .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2001, 280 (05) :1333-1339

[6]

Suppression of okadaic acid-induced apoptosis by overexpression of calpastatin in human UVr-1 cells [J].

Chi, XJ ;

Hiwasa, T ;

Maki, M ;

Sugaya, S ;

Nomura, J ;

Kita, K ;

Suzuki, N .

FEBS LETTERS, 1999, 459 (03) :391-394

[7]

Excitotoxicity-associated p53expression in adult rat retina is mediated by calpain activity but not by Cl-influx..Hama Y;Katsuki H;Izumi Y;et al;.J Pharmacol Sci.2009, 04

← 1 →