丙戊酸钠的抗氧化应激作用在偏头痛中的作用机制

被引：15

作者：

李原超

齐丹丹

张忠玲

机构：

[1] 哈尔滨医科大学附属第一医院神经内科七科

来源：

国际神经病学神经外科学杂志 | 2016年 / 43卷 / 01期

关键词：

偏头痛; 丙戊酸钠; 氧化应激;

D O I：

10.16636/j.cnki.jinn.2016.01.025

中图分类号：

R747.2 [偏头痛];

学科分类号：

100204 [神经病学];

摘要：

近年来,大量研究表明丙戊酸钠对于偏头痛具有显著预防作用,但目前丙戊酸钠对偏头痛预防作用的机制尚不十分清楚。研究发现氧化应激可能通过调节蛋白激酶、谷氨酸能神经传导、神经源性炎症等途径参与偏头痛病理生理过程,而丙戊酸钠可能通过修复线粒体损伤、增加内质网应激蛋白GRP78的表达以及GRP78基因转录率和蛋白水平、抑制诱导型NOS表达、调节抗凋亡因子BCL-2表达、促进大脑脑源性神经生长因子(BDNF)表达等方面降低体内氧化应激水平,由此我们推测丙戊酸钠通过降低偏头痛患者体内氧化应激水平进而对偏头痛发挥预防作用。

引用

页码：90 / 94

页数：5

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