高毒力株幽门螺杆菌感染与慢性原发免疫性血小板减少症的关系及幽门螺杆菌根除治疗的临床疗效

被引：2

作者：

李慧 ^{[1
]}

张晋琳 ^{[1
]}

王小东 ^{[1
]}

王春森 ^{[1
]}

机构：

[1] 四川省人民医院血液科

来源：

中华血液学杂志 | 2011年 / 03期

关键词：

D O I：

暂无

中图分类号：

R558.2 [];

学科分类号：

1002 ; 100201 ;

摘要：

慢性原发免疫性血小板减少症(CITP),以往称慢性特发性血小板减少性紫癜,被认为主要与免疫相关,但免疫治疗仅对部分患者有效,提示CITP的发病还存在其他机制。有研究发现,部分CITP的发生与幽门螺杆菌(Hp)感染有一定关联。临床Hp菌株大体分为两类:Ⅰ类,高毒力株,含有细胞毒素相关基因(CagA基因和VacA基因),并表达CagA蛋白和VacA蛋白;Ⅱ类,低毒力株,仅有VacA基因,不表达

引用

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