早产儿口服布拉氏酵母菌的临床观察

被引：13

作者：

朱将虎 ^{[1
]}

叶晓华 ^{[1
]}

叶伟 ^{[1
]}

陈尚勤 ^{[1
]}

林振浪 ^{[1
]}

机构：

[1] 温州医学院附属第二医院、育英儿童医院新生儿科

来源：

中国新生儿科杂志 | 2012年 / 06期

关键词：

布拉氏酵母菌; 婴儿; 早产; 肠道喂养; 临床观察;

D O I：

暂无

中图分类号：

R722.6 [早产儿疾病];

学科分类号：

100202 ;

摘要：

目的探讨布拉氏酵母菌对早产儿胃肠道功能的影响。方法选择2010年1～12月在我院住院、胎龄28～32周的病情稳定、无消化道疾病的早产儿,随机分为观察组和对照组。观察组予以早产儿配方奶加布拉氏酵母菌100mg/(kg·d)口服,对照组予以单纯早产儿配方奶喂养,连续治疗2～4周至校正胎龄34周。观察并比较两组早产儿体重变化、肠道喂养、黄疸、医院内感染、坏死性小肠结肠炎(NEC)及住院时间等情况。结果观察组入选47例早产儿,对布拉氏酵母菌耐受性良好,均未发生真菌血症。与对照组(43例)比较,观察组生理性体重下降至最低值的日龄小[(4.9±1.7)天比(5.7±1.4)天],恢复出生体重快[(11.6±3.8)天比(13.3±3.9)天],接受光疗时间短[(6.1±1.9)天比(7.2±2.9)天],较早达全胃肠道喂养[(18.3±9.2)天比(23.0±12.4)天],住院时间短[(34.2±16.7)天比(42.2±18.8)天],差异均有统计学意义(P<0.05)。两组生理性体重下降比率、黄疸高峰时间和黄疸最高值、开奶时间以及NEC和败血症发生率差异无统计学意义(P>0.05)。结论早产儿对布拉氏酵母菌耐受性好,布拉氏酵母菌能缩短早产儿达全量胃肠道喂养时间、住院天数和黄疸光疗时间。

引用

页码：398 / 400

页数：3

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