线粒体自噬在脓毒症中的研究进展

被引：7

作者：

张欣桐 ^{[1
]}

刘景卓 ^{[1
]}

李盼 ^{[1
]}

马德胜 ^{[1
]}

马莉 ^{[2
]}

机构：

[1] 兰州大学第二临床医学院

[2] 兰州大学第二医院重症医学科三病区

来源：

中国医药导报 | 2021年 / 18卷 / 10期

关键词：

线粒体自噬; 脓毒症; Parkin; 多器官功能障碍; 治疗;

D O I：

10.20047/j.issn1673-7210.2021.10.010

中图分类号：

R459.7 [急症、急救处理];

学科分类号：

100231 [临床病理学];

摘要：

脓毒症是重症监护病房的常见疾病,具有高发病率、高死亡率的特点,易发生全身多器官损伤甚至衰竭。当前,脓毒症的治疗以病因治疗、液体复苏、抗感染等目标为主,由于病情进展迅速导致治疗效果欠佳。线粒体自噬可通过Parkin依赖性途径和Parkin非依赖性途径清除受损、老化和功能障碍的线粒体,有效避免细胞过度损伤,维持细胞内环境稳态,在许多疾病中发挥重要作用。线粒体自噬在Parkin、Fun14结构相关蛋白1、Bcl-2相互作用蛋白3、线粒体动力学相关蛋白1介导下能够抑制炎症因子和活性氧的释放,减少多器官功能障碍的发生,其在脓毒症中发挥保护作用。本文对线粒体自噬在脓毒症中的作用机制和治疗方面进行综述,旨在为脓毒症的治疗提供新的依据。

引用

页码：39 / 42

页数：4

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