美洛昔康贴剂裸鼠经皮吸收的初步研究

被引：3

作者：

郜琪臻 ^{[1
]}

杨丽英 ^{[2
]}

丁平田 ^{[2
]}

何仲贵 ^{[2
]}

机构：

[1] 中国医科大学第一附属医院药剂科

[2] 沈阳药科大学药学院

来源：

药学学报 | 2007年 / 12期

关键词：

美洛昔康; 微渗析; 经皮吸收; 贴剂;

D O I：

10.16438/j.0513-4870.2007.12.017

中图分类号：

R94 [药剂学];

学科分类号：

100602 ; 100702 ;

摘要：

Meloxicam concentration in skin was determined following topical administration of meloxicam patches in hairless mouse.Samples were analysized by HPLC coupled with microdialysis sampling technique,in which in vivo recovery of probe was characterized by the retrodialysis method.It was indicated that the in vivo recovery of the probe was 14.0%.The range of steady state concentration of meloxicam in dialysate was 24-50 ng·mL-1,and that was 170-360 ng·mL-1 in the hairless mouse skin.Steady state concentration of meloxicam was reached shortly after the application of meloxicam patches,which was maintained during the period of experiment.

引用

页码：1320 / 1322

页数：3