长链非编码RNA DANCR在关节软骨损伤修复中作用机制的研究进展

被引：5

作者：

张聘 ^{[1
]}

杨超 ^{[2
]}

赵建宁 ^{[3
]}

张雷 ^{[3
]}

机构：

[1] 南京医科大学金陵临床医学院(解放军南京总医院)骨科

[2] 南京大学医学院临床学院(解放军南京总医院)骨科

[3] 解放军南京总医院骨科

来源：

转化医学电子杂志 | 2017年 / 4卷 / 03期

关键词：

DANCR; miRNA; 间充质干细胞; 软骨修复;

D O I：

暂无

中图分类号：

R684 [关节疾病及损伤];

学科分类号：

100220 [骨科学];

摘要：

长链非编码RNA(lncRNA)是一类转录本长度超过200个核苷酸但缺乏蛋白质编码功能的RNA,在许多细胞生物过程中发挥重要的调控作用.关节软骨损伤修复一直是关节外科的热点与难点.最近研究表明lncRNA DANCR在间充质干细胞(MSCs)向软骨细胞分化和增殖过程中发挥重要作用.lncRNA DANCR可能通过断裂为miRNA、结合或竞争mRNA/miRNA、增加胞质内β-catenin等途径发挥促软骨损伤修复作用.本文就lncRNA DANCR的结构、功能及在关节软骨损伤修复过程中的可能作用机制作一综述.

引用

页码：62 / 65

页数：4

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