小檗碱改善代谢性疾病的肠道相关机制

被引：8

作者：

姚霜霜

张翼飞

张志国

王卫庆

宁光

机构：

[1] 上海交通大学医学院附属瑞金医院内分泌代谢病科,上海市内分泌代谢病临床医学中心

来源：

国际内分泌代谢杂志 | 2014年 / 34卷 / 06期

关键词：

小檗碱; 2型糖尿病; 肠道激素; 肠道菌群;

D O I：

暂无

中图分类号：

R589 [代谢病];

学科分类号：

100201 [内科学];

摘要：

小檗碱是中药黄连的主要成分,临床上常用作抗菌药物,近年来研究发现其有显著的降血糖、改善代谢性疾病相关症状的作用,但机制尚未完全明确。研究显示,小檗碱可通过影响肠道功能发挥作用,其可能机制包括调控肠道激素分泌、调整肠道菌群结构、改善肠道能量代谢、减轻低水平慢性炎性反应、保护肠道屏障功能等。通过探讨小檗碱改善代谢作用的肠道相关机制,可为小檗碱的临床应用提供理论参考,并为代谢性疾病的治疗方法开拓新思路。

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