氧化苦参碱对环磷酰胺抗癌活性和毒性的影响

被引:45
作者
袁寀
吕式琪
姚娴
机构
[1] 首都医学院药理教研室,首都医学院药理教研室,首都医学院药理教研室北京,北京,北京
关键词
氧化苦参碱; 细胞色素P-450; 环磷酰胺;
D O I
10.16438/j.0513-4870.1987.04.002
中图分类号
学科分类号
摘要
氧化苦参碱能够诱导小鼠肝细胞微粒体细胞色素P-450。氧化苦参碱与环磷酰胺合用对艾氏癌实体型有协同抑制作用,机制之一为氧化苦参碱提高了环磷酰胺的代谢激活,并使环磷酰胺减少剂量1/2,其抑瘤作用仍相当于原剂量,而环磷酰胺引起白细胞降低的毒性明显减轻。
引用
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页码:245 / 249
页数:5
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