大鼠肾血管性高血压动物模型的方法学探讨

被引：3

作者：

谷继

刘裕民

机构：

[1] 暨南大学医学院附属医院胸外科

[2] 湖南医科大学

来源：

暨南大学学报(自然科学与医学版) | 1993年 / 02期

关键词：

大鼠; 高血压; 动物模型; 心肌肥大;

D O I：

暂无

中图分类号：

R541.3 [高血压性心脏病];

学科分类号：

1002 ; 100201 ;

摘要：

用自制0.30 mm内径银夹缩窄大鼠左肾动脉造成了肾血管高血压的发生,高血压发生率为81.5％。高血压动物均发生了明显的左室肥大,全心重/体重(H/B,mg/g)增加65.5％。切除缩窄肾后8周可使血压降至正常,但H/B值明显高于对照组(3.02±0.07vs,2.81±0.04 mg/g,P<0.05)。

引用

页码：29 / 33

页数：5

共 8 条

[1]

Bengis R G,et al.Antihypertensive effect of prolonged blockade of angiotensin formation in benign and malignant one-and two-kidney goldblatt hypertensive rats. Clinical Science . 1979

[2]

Godfrey N,et al.Reversal of renovascuiar hypertension: A comparision of changes in blood pressure, plasma renin and sodium balance in two models in rats. J Laboratory & clinical Medicine . 1985

[3]

Simon Koletsky,et al.Factors determining the success or failure of nephrectomy in experimental renal hypertension. J Laboratory & Clinical Medicine . 1970

[4]

Murphy William R,et al.Effect of graded renal artery constriction on blood pressure, renal artery pressure and plasma renin activity in goldblatt hypertension. Journal of Hypertension . 1984

[5]

Morton J J,et al.The importance of renin-angiotensin system in the development and maintenance of hypertension in the two-kidney, one clip hypertensive rats. Clinical Science . 1983

[6]

James O Davis,et al.Pathogenesis of chronic renovasacular hypertension. Circulation Research . 1977

[7]

Goldblatt H Lynch,et al.Production of persistant elevation of systolic blood pressure by means of renal ischemia. The Journal of Experimental Medicine . 1934

[8]

David R Cross.Animal models in cardiovascular reseach. . 1983

← 1 →