二氢青蒿素抗肿瘤作用及其机制研究进展

被引：13

作者：

陆金健 ^{[1
,2
,3
]}

黄鸣清 ^{[1
,2
,4
]}

陈修平 ^{[1
,2
]}

王一涛 ^{[1
,2
]}

机构：

[1] 澳门大学中药质量研究国家重点实验室

[2] 澳门大学中华医药研究院

[3] 浙江中医药大学生命科学学院

[4] 福建中医药大学药学院

来源：

中国药理学与毒理学杂志 | 2012年 / 26卷 / 03期

关键词：

二氢青蒿素; 抗肿瘤药; 细胞增殖; 新生血管形成; 肿瘤转移;

D O I：

暂无

中图分类号：

R96 [药理学];

学科分类号：

100602 ; 100706 ;

摘要：

二氢青蒿素是青蒿素的重要衍生物,具有显著的抗疟作用。对多种肿瘤动物模型具有一定的肿瘤抑制作用,提示其具有抗肿瘤作用。二氢青蒿素的抗肿瘤作用机制可能与抑制肿瘤细胞增殖包括诱导肿瘤细胞周期阻滞和促进肿瘤细胞凋亡、抑制肿瘤新生血管生成以及抗肿瘤细胞侵袭和转移等有关。细胞内亚铁或亚铁血红素可能是二氢青蒿素抗肿瘤作用的直接靶点。由于二氢青蒿素具有广谱抗肿瘤作用、对正常细胞毒性小及对多药耐药细胞有效等优点,因此有可能被开发为新的抗肿瘤药物。

引用

页码：397 / 401

页数：5

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