LC-MS/MS法定量测定人血浆中阿司匹林及其代谢产物水杨酸

被引：9

作者：

彭翱

周辉

江骥

胡蓓

机构：

[1] 中国医学科学院&中国协和医科大学北京协和医院临床药理研究中心

来源：

分析测试学报 | 2007年 / S1期

关键词：

D O I：

暂无

中图分类号：

R96 [药理学];

学科分类号：

100706 [药理学];

摘要：

A sensitive liquid chromatography-electrospray ionization-tandem mass spectrometric (LC-MS/MS) method for the simultaneous determination of aspirin (ASA) and its metabolite salicylic acid (SA) in human plasma has been developed and validated.The plasma ASA and SA were extracted using a liquid-liquid extraction (LLE) and the sample extract was injected onto the LC-MS/MS system.The limits of quantitation(LLOQ) for ASA and SA are both 25 ng/mL.This method allowed the reproducible and accurate quantification with the concentration rang of 25-10 000 ng/mL.This method could be applied to the quantitation aspirin and salicylic acid in human plasma.

引用

页码：4 / 6

页数：3