TIMP-3、MMP-3与缺血性脑损伤

被引：2

作者：

资晓宏

机构：

[1] 中南大学湘雅三医院神经内科

来源：

国外医学神经病学神经外科学分册. | 2003年 / 05期

关键词：

TIMP-3; MMP-3; 缺血性脑损伤;

D O I：

10.16636/j.cnki.jinn.2003.05.029

中图分类号：

R741 [神经病学];

学科分类号：

1002 ;

摘要：

在脑缺血损伤机制中,基质金属蛋白酶(MMPs)及其内源性抑制剂(TIMPs)的作用日益受到重视。研究表明,TIMP-3、MMP-3及其复合体介导了多种细胞生理和病理发生、发展机制;它们参与了脑缺血再灌注损伤后炎性级联反应及细胞凋亡等机制;同时也参与动脉粥样硬化斑块形成与破裂等。通过研究TIMP-3、MMP-3与脑缺血再灌注损伤的相关性,将有利于脑缺血后神经保护治疗及预防脑缺血发生。

引用

页码：492 / 495

页数：4

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