SIGIRR对IL-1R/TLRs信号通路的负性调控作用研究进展

被引：5

作者：

周秋格 ^{[1
]}

刘畅 ^{[1
]}

刘玉辉 ^{[1
]}

赖金伦 ^{[1
]}

陈颖钰 ^{[1
,2
]}

郭爱珍 ^{[1
,2
]}

胡长敏 ^{[1
,2
]}

机构：

[1] 华中农业大学动物医学院

[2] 农业微生物学国家重点实验室

来源：

中国畜牧兽医 | 2016年 / 43卷 / 10期

关键词：

SIGIRR; TLRs; 信号通路; 负性调控;

D O I：

暂无

中图分类号：

Q75 [分子遗传学];

学科分类号：

071007 [遗传学];

摘要：

单免疫球蛋白白介素1受体相关蛋白(SIGIRR)是TIR超家族成员,最新研究表明它可负性调节IL-1R/TLRs受体介导的固有免疫应答,且在感染性疾病、肿瘤及自体免疫病诱导的炎症反应调节上所起的重要作用已经被阐明。作者主要综述了SIGIRR基因和蛋白表达模式在人、小鼠、牛等物种间的差异性,因其结构特异性所具有的对IL-1R/TLRs炎性信号通路的负性调控和具体的调控机理,以及在不同炎性相关疾病的发生和发展中抑制炎性反应的机制,进而为临床的炎性相关疾病治疗提供理论借鉴,同时也拓宽了SIGIRR基因在动物疾病治疗中的应用范围。

引用

页码：2640 / 2647

页数：8

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