ANGⅡ-AT1ReceptorPathwayIsInvolvedintheAnti-fibroticEffectofβ-elemene

被引：9

作者：

朱锐 ^{[1
]}

杨玲 ^{[2
]}

沈霖 ^{[1
]}

叶进 ^{[2
]}

刘建国 ^{[1
]}

胡胜军 ^{[1
]}

机构：

[1] Department of Traditional Chinese Medicine,Union Hospital,Tongji Medical College,Huazhong University of Science and Technology

[2] Department of Gastroenterology,Union Hospital,Tongji Medical College,Huazhong University of Science and Technology

来源：

Journal of Huazhong University of Science and Technology(Medical Sciences) | 2009年 / 29卷 / 02期

关键词：

D O I：

暂无

中图分类号：

R285.5 [中药实验药理]; R575.2 [肝硬变];

学科分类号：

100201 [内科学]; 100806 [中药药理学];

摘要：

To investigate the effects of β-elemene on the ANGⅡ-AT1 receptor pathway in rats with liver fibrosis, a model of hepatic fibrosis was induced by hypodermical injection of carbon tetrachlo-ride (CCl4) into Wistar male rats. β-elemene was intraperitonealy administered into the rats for 8 weeks (0.1 mL/100 g body weight per day). Masson staining was used to observe the liver fibrosis of rats and liver functions were measured by enzymatic kinetic analysis. The content of hydroxyproline in liver tissues was detected by specimen alkaline hydrolysis. The level of plasma ANGⅡ in blood plasma was detected by radioimmunoassay. The expression of AT1R in rat liver were measured using reverse transcriptional-polymerase chain reaction and immunohistochemistry respectively. The results showed that β-elemene could reduce the collagen disposition in liver and inhibit the progression of liver fibrosis. In addition, the levels of plasma ANGⅡ and the expression of hepatic AT1R in rats with liver fibrosis were also suppressed by β-elemene. It is concluded that the ANGⅡ-AT1 receptor pathway plays an important role in the development of hepatic fibrosis and β-elemene could down-regulate the levels of plasma ANGⅡ and the expression of hepatic AT1R in rats with liver fibrosis.

引用

页码：177 / 181

页数：5

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