ET-1 Lys198Asn和eNOS Glu298Asp基因多态性与原发性高血压及硝苯地平降压疗效的相关性

被引:8
作者
江承设
李栋
余运贤
彭少杰
李建平
黄爱群
徐希平
机构
[1] 中国科学技术大学生命科学学院
[2] 上海市疾病控制中心
[3] 北京大学附属第一医院
关键词
内皮素-1; 一氧化氮合成酶; 多态性; 硝苯地平; 高血压; 降压疗效;
D O I
暂无
中图分类号
R544.1 [高血压];
学科分类号
摘要
目的 研究安徽省 1个高血压人群中内皮素 1 (ET 1 )基因位于第 5号外显子的第 1 98位密码子G/T多态性导致的赖氨酸 /天冬酰胺 (Lys1 98Asn)突变以及内源性一氧化氮合成酶 (eNOS)基因第 2 98位密码子的G/T多态性导致的谷氨酸 /天冬氨酸 (Glu2 98Asp)突变与原发性高血压及抗高血压药物硝苯地平降压疗效的相关性。方法  1 1 0 8例初诊或已停药 2wk以上的原发性高血压病人 ,口服硝苯地平类药物 (拜新同 30mg·d- 1 ) 1 5d。分别按照收缩压及舒张压的降压效果 ,选取降压效果最好及最差的各 1 0 0例病人。这样 ,共 2 93例病人入选该研究。基因型测定采用PCR RFLP方法。分别按收缩压和舒张压 ,对两极端组病人基因多态性与基线血压及降压效果进行分析。结果 在两组极端组组成的总人群中 ,ET 1基因多态性中TT纯合子基因型受试者的基线舒张压〔DBP =(1 0 3 3± 1 6)mmHg〕(1kPa =7 5mmHg)高于带有G等位基因 (GG/GT)的受试者DBP =(99 4± 0 5)mmHg〕 (P =0 0 2 )。ET 1的Lys1 98Asn多态性和eNOS的Glu2 98Asp多态性与拜新同降压效果的关系 ,无论以收缩压还是以舒张压来分 ,均无显著相关性。结论 在该研究的高血压人群中ET 1的Lys1 98Asn多态性与基线舒张压相关。ET 1Lys1 98Asn多态性和eNOSGlu2 98Asp多态性
引用
收藏
页码:875 / 879
页数:5
相关论文
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