脑缺血后脑室下区域神经再生的分子调控

被引：1

作者：

辛晓瑜

陈生弟

机构：

[1] 上海交通大学医学院附属瑞金医院神经内科、上海交通大学医学院神经病学研究所

来源：

国际神经病学神经外科学杂志 | 2007年 / 04期

关键词：

脑室下区域; 脑缺血; 神经再生;

D O I：

10.16636/j.cnki.jinn.2007.04.015

中图分类号：

R743.3 [急性脑血管疾病（中风）];

学科分类号：

100204 [神经病学];

摘要：

脑室下区域是成年高等动物神经再生的关键部位。缺血缺氧性刺激后,在多种转录因子的调控下,脑室下区域细胞分裂明显加速,神经前体细胞数量明显增多,并逐渐向缺血灶周边移行、定居。多种生长因子、一氧化氮系统、基质金属蛋白酶、促红细胞生成素、炎性因子及补体系统等都与脑室下区域神经再生的诱导和调控有关。研究脑缺血后脑室下区域神经再生的调控机制对于卒中后损伤修复具有重要意义,本文将对这一方面的研究进展作一综述。

引用

页码：315 / 318

页数：4

共 16 条

[1]

Bone marrow stromal cells induce BMP2/4 production in oxygen-glucose-deprived astrocytes which promotes an astrocytic phenotype in adult subventricular progenitor cells..Xin H;Li Y;Chen X;Chopp M;.J Neurosci Res.2006, 08

[2]

VEGF-overexpressing transgenic mice show enhanced post-ischemic neurogenesis and neuromigration [J].

Wang, Yaoming ;

Jin, Kunlin ;

Mao, Xiao Ou ;

Xie, Lin ;

Banwait, Surita ;

Marti, Hugo H. ;

Greenberg, David A. .

JOURNAL OF NEUROSCIENCE RESEARCH, 2007, 85 (04) :740-747

[3]

Intracerebral Infusion of Glial Cell Line–Derived Neurotrophic Factor Promotes Striatal Neurogenesis After Stroke in Adult Rats.[J]..Stroke.2006, 9

[4]

Magnetic resonance imaging of the migration of neuronal precursors generated in the adult rodent brain [J].

Shapiro, Erik M. ;

Gonzalez-Perez, Oscar ;

Garcia-Verdugo, Jose Manuel ;

Alvarez-Buylla, Arturo ;

Koretsky, Alan P. .

NEUROIMAGE, 2006, 32 (03) :1150-1157

[5]

Distribution of inducible nitric oxide synthase and cell proliferation in rat brain after transient middle cerebral artery occlusion.[J].Yoshihide Sehara;Takeshi Hayashi;Kentaro Deguchi;Shoko Nagotani;Hanzhe Zhang;Mikio Shoji;Koji Abe.Brain Research.2006, 1

[6]

Vascular endothelial growth factor mediates atorvastatin-induced mammalian achaete-scute homologue-1 gene expression and neuronal differentiation after stroke in retired breeder rats [J].

Chen, J. ;

Zacharek, A. ;

Ll, A. ;

Zhang, C. ;

Ding, J. ;

Roberts, C. ;

Lu, M. ;

Kapke, A. ;

Chopp, M. .

NEUROSCIENCE, 2006, 141 (02) :737-744

[7]

Bone marrow stromal cells upregulate expression of bone morphogenetic proteins 2 and 4, gap junction protein connexin-43 and synaptophysin after stroke in rats [J].

Zhang, C. ;

Li, Y. ;

Chen, J. ;

Gao, Q. ;

Zacharek, A. ;

Kapke, A. ;

Chopp, M. .

NEUROSCIENCE, 2006, 141 (02) :687-695

[8]

Transcription factor protein expression patterns by neural or neuronal progenitor cells of adult monkey subventricular zone [J].

Tonchev, A. B. ;

Yamashima, T. ;

Sawamoto, K. ;

Okano, H. .

NEUROSCIENCE, 2006, 139 (04) :1355-1367

[9]

Enhanced neurogenesis in the ischemic striatum following EGF-induced expansion of transit-amplifying cells in the subventricular zone.[J].Mikiko Ninomiya;Toru Yamashita;Nobuo Araki;Hideyuki Okano;Kazunobu Sawamoto.Neuroscience Letters.2006, 1

[10]

Reduction of the Cell Cycle Length by Decreasing G<sub>1</sub> Phase and Cell Cycle Reentry Expand Neuronal Progenitor Cells in the Subventricular Zone of Adult Rat after Stroke.[J].Rui Lan Zhang;Zheng Gang Zhang;Mei Lu;Ying Wang;James J Yang;Michael Chopp.Journal of Cerebral Blood Flow & Metabolism.2006, 6

← 1 2 →