脂联素及基因多态性与非酒精性脂肪肝的研究进展

被引：11

作者：

叶瑶

于健

机构：

[1] 桂林医学院附属医院内分泌科

来源：

基础医学与临床 | 2014年 / 34卷 / 09期

关键词：

脂联素; 单核苷酸多态性; 非酒精性脂肪肝;

D O I：

10.16352/j.issn.1001-6325.2014.09.014

中图分类号：

R575.5 [肝代谢障碍];

学科分类号：

100201 [内科学];

摘要：

脂联素(APN)作为一种新发现的由脂肪细胞特异性分泌的激素,具有广泛生物学效应,可通过影响肝脏脂肪代谢、炎性因子产生和胰岛素敏感性等,抑制非酒精性脂肪肝(NAFLD)的形成与进展。人脂联素基因启动子区存在相当数量的等位基因单核苷酸多态性(SNPs),而脂联素基因SNPs部分位点与NAFLD发病密切相关,这可能为NAFLD的防治提供了新的途径和方法。

引用

页码：1285 / 1288

页数：4

共 12 条

[1]

AdR1-TG/TALLYHO mice have improved lipid accumulation and insulin sensitivity [J].

Luo, Nanlan ;

Wang, Xiangdong ;

Zhang, Wei ;

Garvey, W. T. ;

Fu, Yuchang .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2013, 433 (04) :567-572

[2]

Pioglitazone prevents hyperglycemia induced decrease of AdipoR1 and AdipoR2 in coronary arteries and coronary VSMCs [J].

Shen, Xuhua ;

Li, Hongwei ;

Li, Weiping ;

Wu, Xing ;

Ding, Xiaosong .

MOLECULAR AND CELLULAR ENDOCRINOLOGY, 2012, 363 (1-2) :27-35

[3]

The ameliorating effect of rosiglitazone on experimental nonalcoholic steatohepatitis is associated with regulating adiponectin receptor expression in rats.[J].Su Liu;Han-Jun Wu;Zong-Qi Zhang;Qing Chen;Bin Liu;Jian-Ping Wu;Liang Zhu.European Journal of Pharmacology.2010, 1

[4]

Adiponectin but not leptin is involved in early hepatic disease in morbidly obese patients.[J].Anna Katharine Hindle;Claire Edwards;Alisha Mendonsa;Marcos Rojkind;Tim McCaffrey;Sidney Fu;Fred Brody.Surgical Endoscopy.2010, 7

[5]

Influence of adiponectin gene polymorphisms in Japanese patients with non-alcoholic fatty liver disease [J].