强迫症的神经内分泌研究

被引：3

作者：

杨彦春

刘协和

机构：

[1] 华西医科大学第一临床医学院心理卫生研究所

来源：

中华精神科杂志 | 1996年 / 02期

关键词：

强迫性人格障碍; 肾上腺皮质激素类; 催乳素;

D O I：

暂无

中图分类号：

R749.7 [神经官能症];

学科分类号：

摘要：

为探讨强迫症患者的下丘脑-垂体-肾上腺皮质系统的功能状态及强迫症与抑郁症的生物学联系,作者对30例未服药的强迫症患者的基础血浆皮质醇、地塞米松抑制试验(DST)及氯丙咪嗪治疗前后的血催乳素含量进行测定,并以20例健康志愿者的血浆皮质醇、DST 和血催乳素测定值作对照。结果显示:强迫症患者基础血浆皮质醇和基础血催乳素含量均高于对照组,但 DST 无一例呈脱抑制反应;患者经氯丙咪嗪治疗后,血浆催乳素含量明显升高。结果提示,强迫症患者有神经内分泌方面异常,但 DST 未见脱抑制现象,不同于抑郁症。氯丙咪嗪的抗强迫症作用与该药对下丘脑5-羟色胺能神经元及多巴胺能神经元的影响有关。

引用

页码：65 / 68

页数：4

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