快速老化小鼠SAMP8在阿尔茨海默病研究中的应用

被引:10
作者
李延峥
李林
张兰
机构
[1] 首都医科大学宣武医院药物研究室,北京市老年病医疗研究中心,神经变性病教育部重点实验室
基金
北京市自然科学基金;
关键词
阿尔茨海默病; 快速老化小鼠; 动物模型; 综述;
D O I
暂无
中图分类号
R749.16 [];
学科分类号
摘要
阿尔茨海默病以进行性认知功能障碍、记忆能力下降为主要特征。脑内β-淀粉样蛋白(Aβ)异常沉积、神经原纤维缠结、胆碱能神经元功能减退、突触和树突棘缺失等为阿尔茨海默病特征性病理改变。快速老化小鼠SAMP8在早期即出现学习记忆功能障碍、Aβ异常沉积、tau蛋白磷酸化、神经递质改变、突触结构和功能障碍、生理节律紊乱,以及基因表达等多方面的特征性改变,与人类阿尔茨海默病病理改变较为一致,可以作为较理想的动物模型,用于阿尔茨海默病防治药物的研究。
引用
收藏
页码:1119 / 1122
页数:4
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