肠道菌群在肠易激综合征中的病理生理作用

被引：36

作者：

朱孟华 ^{[1
]}

史立军 ^{[2
]}

机构：

[1] 哈尔滨医科大学

[2] 哈尔滨医科大学附属第一医院消化内科

来源：

胃肠病学和肝病学杂志 | 2016年 / 25卷 / 01期

关键词：

肠易激综合征; 肠道菌群; 通透性;

D O I：

暂无

中图分类号：

R574 [肠疾病];

学科分类号：

100201 [内科学];

摘要：

肠易激综合征(irritable bowel syndrome,IBS)是一种功能性肠道疾病。其病因是多因素的,如社会心理因素、遗传或环境因素、脑肠轴功能失调、肠道运动障碍、内脏敏感性增高及肠道菌群的改变等。肠道菌群在IBS发病中起重要作用,包括肠道菌群的组成或其代谢活性的变化,激活黏膜免疫和炎症,导致肠道通透性增加和黏膜屏障功能受损,引起肠道感觉运动功能失调和脑肠轴功能紊乱。本文就肠道菌群在IBS的病理生理学上的重要作用作一概述。

引用

页码：105 / 107

页数：3

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