转化生长因子β胞内信号转导与Smads蛋白

被引:31
作者
赵俊芳
刘成
刘成海
机构
[1] 上海中医药大学肝病研究所上海曙光医院,上海中医药大学肝病研究所上海曙光医院,上海中医药大学肝病研究所上海曙光医院上海,上海,上海
关键词
转化生长因子β; 信号转导; Smads蛋白;
D O I
暂无
中图分类号
R341 [];
学科分类号
摘要
Transforming growth factor-β (TGF-β) is a multifunctional peptide growth factor with a wide range of effects. TGF-β signals are conveyed through cell-surface serine/threonine kinase receptors to the downstream cytoplasmic mediators, known as Smads proteins. Receptor-regulated Smads become phosphorylated by activated type Ⅰ receptors and form heteromeric complexes with a common Smad-Smad4, which translocates into the nucleus to regulate gene transcription. Inhibitory Smads inhibit the activation of receptor-regulated Smads. There are positive, negative and feedback regulations in the Smads mediated TGF-β signaling pathway.
引用
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页码:98 / 102
页数:5
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  • [1] TGF- beta induces fibronectin synthesis through a c-jun N-terminal kinasedependent, Smad4 - independent pawhway. Hocevar BA, Brown TL, Howe PH. EMBO Journal . 1999