血脂异常老年人使用他汀类药物中国专家共识

被引:48
作者
刘梅林
胡大一
机构
[1] 血脂异常老年人使用他汀类药物中国专家共识组
[2] 北京大学第一医院老年科
[3] 北京大学人民医院心脏中心
关键词
D O I
暂无
中图分类号
R972 [心血管系统药物];
学科分类号
1007 ;
摘要
<正>随着我国进入老龄化社会,心脑血管疾病已成为影响老年人生存率和生活质量的最重要疾病。随着年龄增长,心脑血管疾病的发病率和病死率增加。大量流行病学研究和前瞻性随机临床试验的结果证实,血脂异常是心脑血管疾病的重要危险因素。近年,随着多项他汀类药物调脂治疗大规模临床试验结果的公布,他汀类药物被视为安全、有效的调脂药物,成为各国心脑血管疾病防治指南推荐的治疗措施。由于多数临床试验是在经过严格筛选的70岁以下心血管疾病及高危患者中完成,临床医师对老年人群尤其是高龄老年人使用他汀类药物是否能同样获益,以及长期治疗的安全性
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共 16 条
[1]  
中国成人血脂异常防治指南[J]. 中华心血管病杂志. 2007(05)
[2]  
Efficacy of cholesterol-lowering therapy in 18 686 people with diabetes in 14 randomised trials of statins: a meta-analysis[J] . Cholesterol Treatment Trialists’ (CTT) Collaborators.The Lancet . 2008 (9607)
[3]  
Suboptimal use of statin therapy in elderly patients with atherosclerosis: A population-based study[J] . Mohammed Al-Omran,Muhammad M. Mamdani,Thomas F. Lindsay,Magda Melo,David N. Juurlink,Subodh Verma.Journal of Vascular Surgery . 2008 (3)
[4]  
Statins for Secondary Prevention in Elderly Patients[J] . Jonathan Afilalo,Gustavo Duque,Russell Steele,J. Wouter Jukema,Anton J.M. de Craen,Mark J. Eisenberg.Journal of the American College of Cardiology . 2008 (1)
[5]  
Hemorrhagic stroke in the Stroke Prevention by Aggressive Reduction in Cholesterol Levels study[J] . L B. Goldstein,P Amarenco,M Szarek,A Callahan,M Hennerici,H Sillesen,J A. Zivin,K M.A. Welch.Neurology . 2008 (24,)
[6]  
Usefulness of Pravastatin in Primary Prevention of Cardiovascular Events in Women: Analysis of the Management of Elevated Cholesterol in the Primary Prevention Group of Adult Japanese (MEGA Study)[J] . Kyoichi Mizuno,Noriaki Nakaya,Yasuo Ohashi,Naoko Tajima,Toshio Kushiro,Tamio Teramoto,Shinichiro Uchiyama,Haruo Nakamura.Circulation . 2008 (4)
[7]  
Effect of Xuezhikang on Cardiovascular Events and Mortality in Elderly Patients with a History of Myocardial Infarction: A Subgroup Analysis of Elderly Subjects from the China Coronary Secondary Prevention Study[J] . PingYe,Zong‐LiangLu,Bao‐minDu,ZuoChen,Yang‐FengWu,Xue‐HaiYu,Yu‐ChengZhao.Journal of the American Geriatrics Society . 2007 (7)
[8]   Effects of high-dose atorvastatin in patients ≥65 years of age with acute coronary syndrome (from the Myocardial Ischemia Reduction with Aggressive Cholesterol Lowering [MIRACL] study) [J].
Olsson, Anders G. ;
Schwartz, Gregory G. ;
Szarek, Michael ;
Luo, Don ;
Jamieson, Michael J. .
AMERICAN JOURNAL OF CARDIOLOGY, 2007, 99 (05) :632-635
[9]  
Effects of Intensive Versus Moderate Lipid-Lowering Therapy on Myocardial Ischemia in Older Patients With Coronary Heart Disease: Results of the Study Assessing Goals in the Elderly (SAGE)[J] . Prakash Deedwania,Peter H. Stone,C Noel Bairey Merz,Juan Cosin-Aguilar,Nevres Koylan,Don Luo,Pamela Ouyang,Ryszard Piotrowicz,Karin Schenck-Gustafsson,Philippe Sellier,James H. Stein,Peter L. Thompson,Dan Tzivoni.Circulation . 2007 (6)
[10]  
Comparison of the lipid-modifying efficacy and safety profiles of ezetimibe coadministered with simvastatin in older versus younger patients with primary hypercholesterolemia: A post Hoc analysis of subpopulations from three pooled clinical trials[J] . Theodore Feldman,Michael Davidson,Arvind Shah,Darbie Maccubbin,Alan Meehan,Michelle Zakson,Diane Tribble,Enrico Veltri,Yale Mitchel.Clinical Therapeutics . 2006 (6)