S-1在消化道肿瘤中的治疗作用

被引：7

作者：

张宁宁

郭晓钟

机构：

[1] 沈阳军区总医院消化内科

来源：

中国新药杂志 | 2010年 / 19卷 / 19期

关键词：

S-1; 胃癌; 胰腺癌; 抗肿瘤作用;

D O I：

暂无

中图分类号：

R735 [消化系肿瘤];

学科分类号：

100112 [医学生物化学与分子生物学];

摘要：

S-1是一种由5-氟尿嘧啶(5-FU)的前体替加氟与两种新的调节药物5-氯-2,4-二羟基吡啶(吉美嘧啶)和氧嗪酸钾(奥替拉西钾)以1∶0.4∶1的比例组成的复合抗癌新药,其在不同肿瘤中均有抗肿瘤作用。在日本,S-1已被批准用于治疗晚期胃癌、头颈部癌、直肠癌、非小细胞肺癌、转移性乳腺癌、胰腺癌和胆管癌等7类肿瘤,且作为治疗晚期胃癌的一线用药。近年来,S-1在消化道肿瘤中的报道相继出现,尤其在胃癌、胰腺癌中的大规模临床研究的报道越来越受到关注。部分研究已显示S-1单药及联合用药在消化道肿瘤中的抗癌作用相对乐观,同时毒副作用低,耐受性好,口服给药方便;另外,S-1还可作为手术患者术后辅助治疗药物。本文就S-1在消化道肿瘤中的应用及价值作一阐述。

引用

页码：1774 / 1777

页数：4

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