淫羊藿总黄酮的抗骨质疏松作用机制

被引：60

作者：

陈克明

机构：

[1] 兰州总医院全军创伤骨科研究所

来源：

中华中医药杂志 | 2017年 / 32卷 / 12期

关键词：

淫羊藿; 总黄酮; 淫羊藿苷; 骨质疏松症;

D O I：

暂无

中图分类号：

R285.5 [中药实验药理];

学科分类号：

100806 [中药药理学];

摘要：

淫羊藿总黄酮是中草药淫羊藿抗骨质疏松的有效部位,主要有效成分包括淫羊藿苷、朝藿定B、朝藿定C和宝藿苷-Ⅰ等。淫羊藿总黄酮具有促进骨形成和抑制骨吸收的双重活性,既可以促进骨髓间充质干细胞的成骨性分化、提高成骨细胞功能,又可以抑制破骨细胞发生及成熟破骨细胞的骨吸收活性。淫羊藿总黄酮通过激活MAPK、BMP/Smad、Wnt/β-catenin和NO信号途径等发挥抗骨质疏松活性,其作为植物性雌激素的作用机制还有待进一步深入研究。

引用

收藏

页码：5485 / 5489

页数：5

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