小剂量碘131联合甲巯咪唑对甲亢患者甲状腺功能及血清CT、PTH、BGP的影响

被引:54
作者
裘佳音
朱燕
奚庆红
机构
[1] 上海市黄浦区香山中医医院内科
关键词
甲亢; 碘131; 甲巯咪唑; 甲状腺功能; 骨代谢;
D O I
10.13210/j.cnki.jhmu.20151218.006
中图分类号
R581.1 [甲状腺机能亢进症];
学科分类号
摘要
目的:观察小剂量碘131联合甲巯咪唑对甲亢患者甲状腺功能及血清CT、PTH、BGP的影响。方法:将纳入研究的104例甲状腺功能亢进(甲亢)患者随机分为观察组(54例)和对照组(50例)。对照组给予甲巯咪唑治疗,观察组在对照组的基础上给予小剂量碘131。治疗2个月,观察两组甲状腺功能(TT3、TT4、FT3、FT4、TSH)及骨代谢相关指标(CT、PTH、BGP)的变化。结果:(1)治疗后,两组TT3、TT4、FT3、FT4均较本组治疗前下降(P<0.05),且观察组降幅更大,两组治疗后同期比较,差异有统计学意义(P<0.05)。两组TSH治疗前后均无明显变化(P>0.05)。(2)治疗后,两组CT、BGP均较本组治疗前下降而PTH上升(P<0.05),且观察组变化幅度更大,两组治疗后同期比较,差异有统计学意义(P<0.05)。结论:小剂量碘131联合甲巯咪唑可较快纠正甲亢患者甲状腺功能及骨代谢异常。
引用
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页码:555 / 557+561 +561
页数:4
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