有氧运动对心肌梗死大鼠心脏交感神经重构的影响

被引：3

作者：

邵承颖 ^{[1
]}

苏冉 ^{[2
]}

王琳 ^{[3
]}

机构：

[1] 山东省举重摔跤柔道运动管理中心

[2] 济南市第一人民医院

[3] 山东体育学院研究生处

来源：

山东体育学院学报 | 2015年 / 31卷 / 03期

关键词：

有氧运动; 心肌梗死; 神经重构; 炎症;

D O I：

10.14104/j.cnki.1006-2076.2015.03.015

中图分类号：

G804.2 [运动生理学];

学科分类号：

摘要：

目的:探讨8周有氧运动对心肌梗死大鼠心脏交感重构的影响及其机制。方法:42只健康雄性SD大鼠随机分为假手术组、心肌梗死组、心肌梗死+有氧运动组。结扎冠状动脉左前降支制备大鼠心肌梗死的模型,术后1周心肌梗死+有氧运动组成活大鼠进行8周跑台运动。采用免疫组织化学方法观察心肌中GAP43、TH阳性神经纤维分布及表达;采用western blot检测心肌中NGF蛋白表达;采用实时定量RT-PCR检测IL-1β及TNF-αmRNA表达。结果:与假手术组大鼠相比,心肌梗死组心肌中GAP43、TH阳性神经纤维密度明显增加(P<0.01),形态粗大且空间分布紊乱;NGF蛋白,IL-1β及TNF-αmRNA表达显著上调。有氧运动干预后心肌组织神经纤维密度明显降低(P<0.01),形态更趋于正常;心肌中NGF、IL-1β及TNF-α表达显著下降。结论:有氧运动减少心肌梗死后心肌局部炎症反应,下调梗死灶周组织NGF表达,抑制交感神经过度再生,从而改善心肌梗死后交感神经重构。

引用

页码：73 / 77

页数：5

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