糖皮质激素与抑郁发病相关机制研究进展

被引:83
作者
陈姣 [1 ]
楚世峰 [2 ]
陈乃宏 [2 ]
机构
[1] 天津中医药大学
[2] 中国医学科学院北京协和医学院药物研究所
基金
北京市自然科学基金;
关键词
抑郁; 糖皮质激素; 后生机制; 糖皮质激素受体(GR); DNA甲基化; FKBP5;
D O I
暂无
中图分类号
R363 [病理生理学];
学科分类号
100103 [病原生物学];
摘要
抑郁症是一种情感障碍性疾病,临床上以兴趣缺乏、情绪低落、睡眠障碍等为主要病症表现,部分患者常伴有自杀倾向。目前研究的抑郁发病机制主要有:单胺假说、神经营养再生假说、神经内分泌假说、表观遗传学假说。近年来的研究发现糖皮质激素和其受体在抑郁的发病机制中起着重要的作用。糖皮质激素是肾上腺分泌的一种激素,在长期应激的作用下,HPA轴持续激活,导致糖皮质激素的持续分泌,引起神经内分泌系统紊乱,在抑郁的发病机制中有重要意义。该文主要针对糖皮质激素及其受体对抑郁发病相关机制的研究进展进行综述。
引用
收藏
页码:1493 / 1495
页数:3
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