LPS信号转导分子TLR4表达与小鼠肝损伤的关系

被引:5
作者
刘小伟
游宇
卢放根
羊东晔
欧阳春晖
吴小平
机构
[1] 中南大学湘雅二医院消化内科,中南大学湘雅二医院消化内科,中南大学湘雅二医院消化内科,中南大学湘雅二医院消化内科,中南大学湘雅二医院消化内科,中南大学湘雅二医院消化内科长沙,长沙,长沙,长沙,长沙,长沙
关键词
脂多糖; 肝脏; Toll样受体4; 小鼠;
D O I
暂无
中图分类号
R575 [肝及胆疾病];
学科分类号
1002 ; 100201 ;
摘要
目的 :探讨脂多糖 (lipopolysaccharide ,LPS)信号转导分子TLR4(Toll likereceptor 4 ,TLR4)与肝脏损伤的关系。方法 :小鼠腹腔注射LPS后不同时间点取肝脏组织 ,HE染色观察病理改变 ,RT PCR法检测肝组织TLR4mRNA的表达。结果 :腹腔注射LPS后 2 4h小鼠肝脏出现明显炎性浸润、坏死 ,肝组织TLR4mRNA的表达在注射LPS后 6 ,1 2h明显抑制 ,2 4h则基本恢复。结论 :LPS致肝损伤呈时间依从性 ;LPS信号转导分子TLR4在介导LPS肝损伤中起重要作用
引用
收藏
页码:217 / 220
页数:4
相关论文
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