骨髓基质细胞基因表达的研究进展

被引：10

作者：

韩冰

付小兵

孙晓庆

机构：

[1] 解放军总医院临床部全军创伤修复重点实验室,解放军总医院临床部全军创伤修复重点实验室,解放军总医院临床部全军创伤修复重点实验室北京,解放军第医院,北京,,北京,

来源：

中国修复重建外科杂志 | 2005年 / 02期

关键词：

骨髓基质细胞; 基因表达; 分化;

D O I：

暂无

中图分类号：

R346 [];

学科分类号：

1001 ;

摘要：

目的　介绍骨髓基质细胞 (marrow stromal cells,MSCs)基因表达与其生物学特性、诱导分化、基因治疗、造血调控和创伤修复中的炎症反应等方面的研究进展。　方法　查阅国内外近年有关文献 ,并做综合分析。　结果MSCs不仅能在不同的条件下表达中胚层、内胚层和外胚层的特异性基因 ,而且能稳定地表达转导的外源基因 ,并且对造血系统有支持作用 ,也参加创伤修复过程中的炎症反应。　结论　 MSCs是一种具有自我更新和多向分化潜能的干细胞 ,且体外易于扩增 ,是一种理想的细胞治疗和基因治疗的靶细胞。

引用

页码：153 / 158

页数：6

共 9 条

[1] 骨髓间充质干细胞分化为血管内皮细胞的实验研究 [J].

方利君 ;

付小兵 ;

孙同柱 ;

李建福 ;

程飚 ;

杨银辉 ;

王玉新 .

中华烧伤杂志, 2003, (01) :22-24

[2] Human bone marrow stem cells exhibit neural phenotypes and ameliorate neurological deficits after grafting into the ischemic brain of rats [J].

Zhao, LR ;

Duan, WM ;

Reyes, M ;

Keene, CD ;

Verfaillie, CM ;

Low, WC .

EXPERIMENTAL NEUROLOGY, 2002, 174 (01) :11-20

[3] Genome-wide screening by cDNA microarray of genes associated with matrix mineralization by human mesenchymal stem cells in vitro [J].

Doi, M ;

Nagano, A ;

Nakamura, Y .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2002, 290 (01) :381-390

[4]

Chondrogenic Differentiation of Mesenchymal Stem Cells from Bone Marrow: Differentiation-Dependent Gene Expression of Matrix Components[J] . Frank Barry,Raymond E. Boynton,Beishan Liu,J.Mary Murphy.Experimental Cell Research . 2001 (2)

[5]

Multipotency of a Bone Marrow Stromal Cell Line, TBR31-2, Established from ts-SV40 T Antigen Gene Transgenic Mice[J] . Yoichi Negishi,Akihiko Kudo,Akiko Obinata,Kohtaro Kawashima,Hiroshi Hirano,Nobuaki Yanai,Masuo Obinata,Hiroyoshi Endo.Biochemical and Biophysical Research Communications . 2000 (2)

[6] Adenoviral-mediated gene transfer into ex vivo expanded human bone marrow mesenchymal progenitor cells [J].

Conget, PA ;

Minguell, JJ .

EXPERIMENTAL HEMATOLOGY, 2000, 28 (04) :382-390

[7]

Selection, enrichment, and culture expansion of murine mesenchymal progenitor cells by retroviral transduction of cycling adherent bone marrow cells[J] . Yukie Kitano,Antonetta Radu,Aimen Shaaban,Alan W. Flake.Experimental Hematology . 2000 (12)

[8] Identification and enrichment of human osteoprogenitor cells by using differentiation stage-specific monoclonal antibodies [J].

Joyner, CJ ;

Bennett, A ;

Triffit, JT .

BONE, 1997, 21 (01) :1-6

[9]

Curcumin, a compound with anti -inflammatory and anti -oxidant properties,down-regulates chemokine expression in bone marrow stromal cells. Xu YX, Pindolia KP, Janakiraman N, et al. Experimental Hematology . 1997

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