抗氧化剂在糖尿病中的应用研究进展

被引：43

作者：

金雷 ^{[1
]}

薛宏宇 ^{[1
]}

金礼吉 ^{[1
]}

李淑英 ^{[2
]}

徐永平 ^{[1
]}

机构：

[1] 大连理工大学环境与生命学院生物科学与工程系

[2] 大连赛姆生物工程技术有限公司

来源：

现代生物医学进展 | 2008年 / 02期

基金：

国家杰出青年科学基金;

关键词：

抗氧化剂; 糖尿病; 氧化应激;

D O I：

10.13241/j.cnki.pmb.2008.02.049

中图分类号：

R587.1 [糖尿病];

学科分类号：

100201 [内科学];

摘要：

氧化应激是自由基的促氧化与机体的抗氧化失衡造成的自由基的高反应活性可以使细胞组分发生化学变化,并导致脂质过氧化。越来越多的证据表明:糖尿病患者体内活性氧物质明显增多,并且抗氧化防御系统功能紊乱。抗氧化剂可以降低糖尿病患者体内的氧化应激水平,清除自由基并改善抗氧化防御体系,所以将抗氧化剂应用于糖尿病是可行的。许多抗氧化剂已经用于糖尿病的研究与治疗,本文主要将作用于糖尿病的各种抗氧化剂做一综述。

引用

页码：383 / 385

页数：3

共 9 条

[1]

Free radical-scavenging activity of Korean red ginseng for erectile dysfunction in non-insulin-dependent diabetes mellitus rats [J].

Ryu, JK ;

Lee, T ;

Kim, DJ ;

Park, IS ;

Yoon, SM ;

Lee, HS ;

Song, SU ;

Suh, JK .

UROLOGY, 2005, 65 (03) :611-615

[2]

Metformin decreases intracellular production of reactive oxygen species in aortic endothelial cells [J].

Ouslimani, N ;

Peynet, J ;

Bonnefont-Rousselot, D ;

Thérond, P ;

Legrand, A ;

Beaudeux, JL .

METABOLISM-CLINICAL AND EXPERIMENTAL, 2005, 54 (06) :829-834

[3]

Effects of pentoxifylline on oxidative stress and levels of EGF and NO in blood of diabetic type-2 patients; a randomized, double-blind placebo-controlled clinical trial [J].

Radfar, M ;

Larijani, B ;

Hadjibabaie, M ;

Rajabipour, B ;

Mojtahedi, A ;

Abdollahi, M .

BIOMEDICINE & PHARMACOTHERAPY, 2005, 59 (06) :302-306

[4]

Zinc might protect oxidative changes in the retina and pancreas at the early stage of diabetic rats [J].

Moustafa, SA .

TOXICOLOGY AND APPLIED PHARMACOLOGY, 2004, 201 (02) :149-155

[5]

Protective effect of macrocyclic binuclear oxovanadium complex on oxidative stress in pancreas of streptozotocin induced diabetic rats [J].

Ramachandran, B ;

Ravi, K ;

Narayanan, V ;

Kandaswamy, M ;

Subramanian, S .

CHEMICO-BIOLOGICAL INTERACTIONS, 2004, 149 (01) :9-21

[6]

Diabetes-induced activation of nuclear transcriptional factor in the retina, and its inhibition by antioxidants [J].

Kowluru, RA ;

Koppolu, P ;

Chakrabarti, S ;

Chen, SL .

FREE RADICAL RESEARCH, 2003, 37 (11) :1169-1180

[7]

Free radicals, antioxidants, and nutrition [J].

Fang, YZ ;

Yang, S ;

Wu, GY .

NUTRITION, 2002, 18 (10) :872-879

[8]

Oxidative Stress and Cardiovascular Disease in Type 2 Diabetes: The Role of Antioxidants and Pro-Oxidants.[J].Sue Penckofer;Dorie Schwertz;Kristine Florczak.The Journal of Cardiovascular Nursing.2002, 2

[9]

Potential antioxidant effects of zinc and chromium supplementation in people with type 2 diabetes mellitus [J].

Anderson, RA ;

Roussel, AM ;

Zouari, N ;

Mahjoub, S ;

Matheau, JM ;

Kerkeni, A .

JOURNAL OF THE AMERICAN COLLEGE OF NUTRITION, 2001, 20 (03) :212-218

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