一氧化碳,生物体内又一种重要的气体信使

被引:7
作者
黄巧冰
赵克森
机构
[1] 第一军医大学病理生理教研室!广东广州,第一军医大学病理生理教研室!广东广州
基金
广东省自然科学基金;
关键词
一氧化碳; 气体; 信号传递;
D O I
暂无
中图分类号
R341 [];
学科分类号
1001 ;
摘要
Endogenous carbon monoxide (CO) is proposed to be an intracellular signaling molecule. As a new gaseous messenger, CO shares with nitric oxide (NO) the ability of modulating neuroendocrine function and inducing vasorelaxation, mainly by stimulating soluble guanylate cyclase and regulating the level of cGMP. This review emphasized the endogenous source of CO and the interaction of CO- and NO-generating systems. It also discussed the biological effects of CO and the underlying mechanisms.
引用
收藏
页码:81 / 84
页数:4
相关论文
共 27 条
[1]  
The chemical modification of Kca channels by carbon monoxide in vascular smooth muscle cell. Wang R,Wu L,Wang Z. Journal of Biological Chemistry . 1997
[2]  
Carbon monoxide relaxes ilial smooth muscle through activation of guanylate cyclase. Utz J,Ullrich V. Biochemical Pharmacology . 1991
[3]  
Mapping of neural nitric oxide synthase in the rat suggests frequent colocalization with NADPH diaphorase but not with soluble guanylate cyclase, and novel paraneural functions for nitronergic signal transduction. Schmidt HH,Gacne CD,Nokong M,et al. Journal of Histochemistry and Cytochemistry . 1992
[4]  
Histochemicalmappingofnitricoxidesynthaseintheratbrain. VincentSR,KimuraGK. Neuroscience . 1992
[5]  
Nitric oxide-a retrograde messenger for carbon monoxide signaling in ischemic heart. Maulik N,Engerman DT,Watanabe M,et al. Molecular and Cellular Biochemistry . 1996
[6]  
Evidenceforacyclicguanosinemonophosphate -dependent,carbonmonoxide -mediated ,signalingsystemintheregulationofTNF -αproductionbyhumanpulmonarymacrophages. Arias -DiazJ,VaraE,GarciaC,etal. Archives of Surgery . 1995
[7]  
Role of endothelial carbon monoxide in attenuated vasoreactivity following chronic hypoxia. Caudill TK,Resta TC,Kanagy NL,et al. American Journal of Physiology . 1998
[8]  
Carbon monoxide-induced vasorelaxation and the underlying mechanisms. Wang R,Wang Z,Wu L. British Journal of Pharmacology . 1997
[9]  
Mechanisms of carbon monoxide toxicity. Coburn RF. Preventive Medicine . 1979
[10]  
Carbon monoxide: A putative neural messenger. Verma A,Hirsch DJ,Glatt CE,et al. Science . 1993