人工肝在肝衰竭治疗中的应用

被引：25

作者：

段学章

辛绍杰

机构：

[1] 解放军第三○二医院肝衰竭诊疗与研究中心

来源：

中华肝脏病杂志 | 2012年 / 06期

关键词：

肝功能衰竭; 肝,人工; 治疗;

D O I：

暂无

中图分类号：

R575.3 [肝功能衰竭];

学科分类号：

100201 [内科学];

摘要：

<正>肝衰竭病死率达60%～70%,目前为止,肝移植仍是最有效的治疗手段。如何降低和减轻肝衰竭患者的并发症,为肝移植赢得时间,甚至使部分患者不需要肝移植,是目前面临的重要课题。人工肝支持(artificial liver support,ALS)治疗的目的是稳定患者内环境,帮助患者清除毒素,促进肝细胞再生和功能恢复,为肝移植赢得时间甚至不需进行肝移植。ALS目前可分为3类,即非生物型、生物型和混合型人工肝3种。生物型或混合型ALS需要在

引用

共 9 条

[1]

6 EXTRACORPOREAL LIVER SUPPORT BY FRACTIONATED PLASMA SEPARATION AND ADSORPTION (PROMETHEUS) IN PATIENTS WITH ACUTE-ON-CHRONIC LIVER FAILURE (HELIOS STUDY): A PROSPECTIVE RANDOMIZED CONTROLLED MULTICENTER STUDY.[J].K. Rifai;A. Kribben;G. Gerken;S. Haag;S. Herget-Rosenthal;U. Treichel;C. Betz;C. Sarrazin;H. Van Vlierberghe;E. Hoste;à. Escorsell;P. Ginès;C. Hafer;M. Schuchmann;P.R. Galle;M. Bernardi;P. Caraceni;D. Abeles;F. Berr;M. Knotek;J. Kozik-Jaromin.Journal of Hepatology.2010,

[2]

Induction of pluripotent stem cells from adult human fibroblasts by defined factors [J].

Takahashi, Kazutoshi ;

Tanabe, Koji ;

Ohnuki, Mari ;

Narita, Megumi ;

Ichisaka, Tomoko ;

Tomoda, Kiichiro ;

Yamanaka, Shinya .

CELL, 2007, 131 (05) :861-872

[3]

Growth and metabolism of human hepatocytes on biomodified collagen poly(lactic-co-glycolic acid) three-dimensional scaffold [J].

Li, J ;

Li, LJ ;

Yu, HW ;

Cao, HC ;

Gao, CY ;

Gong, YH .

ASAIO JOURNAL, 2006, 52 (03) :321-327

[4]

Treatment of severe refractory pruritus with fractionated plasma separation and adsorption (Prometheus?).[J].Kinan Rifai;Carsten Hafer;Jens Rosenau;Christoph Athmann;Hermann Haller;Michael Peter Manns;Danilo Fliser.Scandinavian Journal of Gastroenterology.2006, 10

[5]

Effect of albumin dialysis on intracranial pressure increase in pigs with acute liver failure: A randomized study [J].

Sen, S ;

Rose, C ;

Ytrebo, LM ;

Davies, NA ;

Nedredal, GI ;

Drevland, SS ;

Kjonno, M ;

Prinzen, FW ;

Hodges, SJ ;

Deutz, NEP ;

Williams, R ;

Butterworth, RF ;

Revhaug, A ;

Jalan, R .

CRITICAL CARE MEDICINE, 2006, 34 (01) :158-164

[6]

In vivo quantification of liver dialysis: Comparison of albumin dialysis and fractionated plasma separation [J].

Krisper, P ;

Haditsch, B ;

Stauber, R ;

Jung, A ;

Stadlbauer, V ;

Trauner, M ;

Holzer, H ;

Schneditz, D .

JOURNAL OF HEPATOLOGY, 2005, 43 (03) :451-457

[7]

Prospective, randomized, multicenter, controlled trial of a bioartificial liver in treating acute liver failure [J].

Demetriou, AA ;

Brown, RS ;

Busuttil, RW ;

Fair, J ;

McGuire, BM ;

Rosenthal, P ;

Esch, JSA ;

Lerut, J ;

Nyberg, SL ;

Salizzoni, M ;

Fagan, EA ;

de Hemptinne, B ;

Broelsch, CE ;

Muraca, M ;

Salmeron, JM ;

Rabkin, JM ;

Metselaar, HJ ;

Pratt, D ;

De La Mata, M ;

McChesney, LP ;

Everson, GT ;

Lavin, PT ;

Stevens, AC ;

Pitkin, Z ;

Solomon, BA .

ANNALS OF SURGERY, 2004, 239 (05) :660-667

[8]

Clinical extracorporeal hybrid liver support – phase I study with primary porcine liver cells.[J].I. M.Sauer;D.Kardassis;K.Zeillinger;A.Pascher;A.Gruenwald;G.Pless;M.Irgang;M.Kraemer;G.Puhl;J.Frank;A. R.Müller;TH.Steinmüller;J.Denner;P.Neuhaus;J. C.Gerlach.Xenotransplantation.2003, 5

[9]

人肝细胞离线混合生物人工肝支持系统的构建与实验研究 [J].

荣义辉 ;

刘鸿陵 ;

游绍莉 ;

刘婉姝 ;

胡燕 ;

侯俊 ;

貌盼勇 ;

辛绍杰 .

中华实验和临床病毒学杂志, 2010, (03)

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