升压联合亚低温治疗对局灶性脑缺血再灌注的脑保护作用

被引：9

作者：

刘传玉

李承晏

曾庆杏

机构：

[1] 武汉大学人民医院神经内科

来源：

卒中与神经疾病 | 2002年 / 02期

关键词：

大鼠; 脑缺血/再灌注; 升压; 亚低温;

D O I：

暂无

中图分类号：

R741.02 [神经病理学、病因学];

学科分类号：

0710 ; 071006 ;

摘要：

目的　观察升压联合亚低温治疗对大鼠局灶性脑缺血再灌注的脑保护作用。方法　 32只大鼠随机分为对照组、升压组、亚低温组、升压 +亚低温组 ,采用大鼠局灶性脑缺血再灌注模型 ,观察各组神经功能缺损评分和脑梗死体积。结果　升压组、亚低温组及升压 +亚低温组神经功能缺损评分 (P <0 .0 5 )、脑梗死体积 (P <0 .0 1)均明显低于对照组 ;升压 +亚低温组脑梗死体积明显低于升压组和亚低温组 (P <0 .0 5 )。结论　升压、亚低温对局灶性脑缺血再灌注损伤有明显脑保护作用 ,升压联合亚低温应用效果更佳

引用

页码：110 / 112

页数：3

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