铜绿假单胞菌群体感应抑制剂研究进展

被引：4

作者：

邹姗姗

宫倩红

尹守亮

于文功

机构：

[1] 中国海洋大学医药学院海洋药物教育部重点实验室

来源：

现代生物医学进展 | 2010年 / 10卷 / 05期

关键词：

铜绿假单胞菌; 群体感应; 抑制剂;

D O I：

10.13241/j.cnki.pmb.2010.05.060

中图分类号：

R978.1 [抗生素];

学科分类号：

100705 ;

摘要：

铜绿假单胞菌是一种常见的机会致病菌,可在人群中引起严重的急性和慢性感染,是病人在医院期间发生感染的第三大致病菌。铜绿假单胞菌多种毒力因子的分泌以及生物被膜的形成都是受一种被称为群体感应(Quorum Sensing,QS)的胞间信号传导系统调控的。QS使细菌能够根据细胞密度变化进行基因表达的调控。通过抑制QS来治疗铜绿假单胞菌感染是一个很有前景的发展方向。本文将就近年来铜绿假单胞菌群体感应抑制剂的研究进展进行综述。

引用

页码：949 / 953

页数：5

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