乳腺浸润性导管癌中COX-2、MMP-9的表达及临床意义

被引：8

作者：

孙春雷

王祥军

周士福

时伟锋

孟东

吕庆

机构：

[1] 苏州大学附属第四医院

来源：

现代肿瘤医学 | 2010年 / 18卷 / 03期

关键词：

乳腺癌; 环氧合酶-2; 基质金属蛋白酶-9;

D O I：

暂无

中图分类号：

R737.9 [乳腺肿瘤];

学科分类号：

摘要：

目的:探讨COX-2和MMP-9蛋白在乳腺浸润性导管癌组织中的表达及其相关性。方法:应用免疫组织化学法检测52例乳腺癌组织COX-2和MMP-9蛋白的表达。结果:乳腺浸润性导管癌组织中COX-2阳性表达率为76.9%(40/52),MMP-9阳性表达率为82.7%(43/52),COX-2阳性表达与患者的年龄、肿瘤大小、雌孕激素受体无明显相关性(P>0.05),而与淋巴结转移、TNM分期、组织学分级有关(P<0.05);MMP-9阳性表达与患者的年龄、雌孕激素受体无明显相关性(P>0.05),而与肿瘤大小、淋巴结转移、TNM分期、组织学分级有关(P<0.05);乳腺浸润性导管癌组织中COX-2、MMP-9蛋白的表达之间存在显著正相关(r=0.448,P<0.01)。结论:乳腺浸润性导管癌组织中COX-2、MMP-9蛋白高表达,且两者具相关性。COX-2蛋白可通过诱导MMP-9蛋白的表达上调,增加乳腺癌细胞的侵袭力,促进乳腺癌浸润、转移。

引用

页码：480 / 482

页数：3

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